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  • Basic Info
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Generic: atovaquone-proguanil
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It is used to prevent and to treat malaria infections

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What is this medicine?

ATOVAQUONE; PROGUANIL (a TOE va kwone; pro GWAN il) is an antimalarial agent. It is used to prevent and to treat malaria infections.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • kidney disease
  • liver disease
  • stomach problems
  • an unusual or allergic reaction to atovaquone, proguanil, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast- feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine at the same time each day with food or a milky drink. The tablets may be crushed and mixed with condensed milk just before the dose. If you vomit within 1 hour after taking your dose, take your dose again. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early. To prevent malaria, take this medicine daily starting 1 or 2 days before entering the area, and continue for 7 days after leaving.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • metoclopramide
  • rifabutin
  • rifampin
  • tetracycline

What should I watch for while using this medicine?

If you get a fever during or after you are in a malaria- endemic area, call your doctor. Tell your doctor that you may have been exposed to malaria.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/ booths.

While in areas where malaria is common, take steps to prevent mosquito bites.

- Stay in air- conditioned or well- screened rooms to reduce human- mosquito contact.
- Sleep under mosquito netting, preferably one with pyrethrum- containing insecticide.
- Wear long- sleeved shirts or blouses and long trousers to protect arms and legs.
- Apply mosquito repellents containing DEET to uncovered areas of skin.
- Use a pyrethrum- containing flying insect spray to kill mosquitoes.

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