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  • Basic Info
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Generic: arginine
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a hormone - treats Burns, Peripheral vascular disease / claudication, Infertility, Interstitial cystitis, Dental pain, Heart protection during coronary artery bypass grafting, Immunomodulator, Exercise performance, Migraine headache, Kidney disease or failure, Transplants, Senile dementia, Cyclosporine toxicity, Critical illness, Adrenoleukodystrophy, Respiratory infections, Pre-eclampsia, Autonomic failure, Growth hormone reserve test / pituitary disorder diagnosis, Kidney protection during angiography, Chemotherapy adjuvant, MELAS syndrome, Raynaud's phenomenon, Heart failure, Chest pain, Anal fissures, Erectile dysfunction, Altitude sickness, Coronary artery disease / angina, High blood pressure, Wound healing, Asthma, Recovery after surgery, Myocardial infarction, Diabetes, Diabetic complications, Pressure ulcers, High cholesterol, Circulation problems, Gastrointestinal cancer surgery, Breast cancer, Intrauterine growth retardation, and Inborn errors of urea synthesis and prevents Prevention of restenosis after coronary angioplasty

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This information is based on a professional level monograph edited and peer- reviewed by contributors to the Natural Standard Research Collaboration ( Heather Boon, BScPhm, PhD (University of Toronto); Ethan Basch, MD (Memorial Sloan- Kettering Cancer Center); Michelle Corrado, PharmD (Harvard Vanguard Medical Associates); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Sadaf Hashmi MD, MPH (Johns Hopkins School of Hygiene and Public Health); Jenna Hollenstein, MS, RD (Natural Standard Research Collaboration); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

Abel T, Knechtle B, Perret C, et al. Influence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism - a randomized, double- blind, placebo- controlled study. Int J Sports Med 2005 Jun;26(5):344- 9.

Angdin M, Settergren G, Liska J, et al. No effect of L- arginine supplementation on pulmonary endothelial dysfunction after cardiopulmonary bypass. Acta Anaesthesiol Scand 2001;45(4):441- 8.

Bednarz B, Jaxa- Chamiec T, Maciejewski P, et al. Efficacy and safety of oral l- arginine in acute myocardial infarction. Results of the multicenter, randomized, double- blind, placebo- controlled ARAMI pilot trial. Kardiol Pol 2005;62(5):421- 7.

Carrier M, Pellerin M, Perrault LP, et al. Cardioplegic arrest with L- arginine improves myocardial protection: results of a prospective randomized clinical trial. Ann Thorac Surg 2002;73(3):837- 41; discussion 842.

Cartledge JJ, Davies AM, Eardley I. A randomized double- blind placebo- controlled crossover trial of the efficacy of L- arginine in the treatment of interstitial cystitis. BJU Int 2000;85(4):421- 426.

Facchinetti F, Saade GR, Neri I, et al. L- arginine supplementation in patients with gestational hypertension: a pilot study. Hypertens Pregnancy 2007;26(1):121- 30.

Houwing RH, Rozendaal M, Wouters- Wesseling W, et al. A randomised, double- blind assessment of the effect of nutritional supplementation on the prevention of pressure ulcers in hip- fracture patients. Clin Nutr 2003;22(4):401- 405.

Kimber J, Watson L, Mathias CJ. Cardiovascular and neurohormonal responses to i. v. l- arginine in two groups with primary autonomic failure. J Neurol 2001;248(12):1036- 41.

Kawano H, Motoyama T, Hirai N, et al. Endothelial dysfunction in hypercholesterolemia is improved by L- arginine administration: possible role of oxidative stress. Atherosclerosis 2002;161(2):375- 80.

Oka RK, Szuba A, Giacomini JC, et al. A pilot study of L- arginine supplementation on functional capacity in peripheral arterial disease. Vasc Med 2005;10(4):265- 74.

Polan ML, Hochberg RB, Trant AS, et al. Estrogen bioassay of ginseng extract and ArginMax, a nutritional supplement for the enhancement of female sexual function. J Womens Health (Larchmt) 2004;13(4):427- 430.

Schramm L, La M, Heidbreder E, Hecker M, et al. L- arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation. Kidney Int 2002;61(4):1423- 32.

Schulman SP, Becker LC, Kass DA, et al. L- arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA 2006;295(1):58- 64.

Suzuki T, Hayase M, Hibi K, et al. Effect of local delivery of L- arginine on in- stent restenosis in humans. Am J Cardiol 2002;89(4):363- 7.

Yin WH, Chen JW, Tsai C, et al. L- arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease. Clin Nutr 2005;24(6):988- 97.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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