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  • Basic Info
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Generic: arabinoxylan
treats Cancer and Diabetes
               



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Interactions

Interactions with Drugs

MGN- 3 may be safely and advantageously used with chemotherapy and radiation to increase the cytotoxic effect of the therapy and to decrease adverse side effects. A qualified healthcare practitioner, including a pharmacist, should be consulted before combining arabinoxylan with other medications or therapies.

Arabinoxylan may reduce blood sugar levels, and could theoretically interact with blood sugar lowering medications taken by mouth or insulin.

Arabinoxylan may possess immuno- stimulant properties, and could theoretically interact with other drugs that alter the immune system. Caution is advised.

Interactions with Herbs and Dietary Supplements

Preparations of MGN- 3 (BioBran®) arabinoxylan product contain unclear amounts of calcium and phosphorous.

Arabinoxylan may reduce blood sugar levels, and could theoretically interact with blood sugar lowering herbs and supplements.

Arabinoxylan may possess immuno- stimulant properties, and could theoretically interact with other herbs and supplements that alter the immune system. Caution is advised.

Attribution

This information is based on a professional level monograph edited and peer- reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Samuel D. Benjamin, M.D (Humana Inc.); Rebecca Bramwell, PharmD (Massachusetts College of Pharmacy); Nicole Giese, MS (Natural Standard Research Collaboration); Ernest Hawkins, BSPharm, RPh (Natural Standard Research Collaboration); Erica Rusie, PharmD (Nova Southeastern University); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Verda Tunaligil, MD, MPH (Harvard School of Public Health); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Northeastern University).

Bibliography

DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Anonymous. Clinical Research Using MGN- 3. Cancer: the interface between basic and applied research 2001.

Ghoneum M, Jewett A. Synergistic effect of modified arabinoxylane (MGN- 3) and low dose of recombinant IL- 2 on human NK cell activity and TNF- a production. American Academy of Anti- Aging Medicine, Education Conference 1998.

Ghoneum M, Maeda H. MGN- 3 immunotherapy for the treatment of cancer [abstract]. First International Symposium on Disease Prevention by IP- 6 and other Rice Components 1998.

Ghoneum M, Namatalla G. NK Immunomodulatory function in 27 cancer patients by MGN- 3, a modified arabinoxylane from rice bran. 87th Annual Meeting of the American Association for Cancer Research 1996.

Ghoneum M, Namatalia G, Kim C. Effect of MGN- 3 on human natural killer cell activity and interferon- y synthesis in vitro. FASEB 1996;10(6):26- 32.

Ghoneum M. Enhancement of human natural killer cell activity by modified arabinoxylane from rice bran (MGN- 3). Int J Immunotherapy 1998;14:89- 99.

Ghoneum M. NK immunorestoration of cancer patients by MGN- 3, a modified arabinoxylan rice bran (study of 32 patients followed up to four years). 6th International Congress on Anti- Aging and Bio- Medical Technologies 1998.

Ghoneum MH. Immunomodulatory and anti- cancer properties of (MGN- 3), a modified xylose from rice bran, in five patients with breast cancer. American Association for Cancer Research Special Conference: The interface between basic and applied research 1995.

Ghoneum MH. One sizeable step for immunology, one giant leap for cancer patients. Townsend Letter for Doctors and Patients 2000;58- 62.

Ghoneum M. Anti- HIV activity in vitro of MGN- 3, an activated arabinoxylane from rice bran. Biochem Biophys.Res Commun. 2- 4- 1998;243(1):25- 29.

Ghoneum M, Vojdani A, Banionis A, et al. The effects of carcinogenic methylcholanthrene on carbohydrate residues of NK cells. Toxicol.Ind Health 1997;13(6):727- 741.

Jacoby H, Wnorowski G, Sakata K, et al. The effect of MGN- 3 on cisplatin and adriamycin induced toxicity in the rat [abstract]. Supplement to Gastroenterology 2000;18(4):4962.

Kanari M, Tomoda M, Gonda R, et al. A reticuloendothelial system- activating arabinoxylan from the bark of Cinnamomum cassia. Chem Pharm Bull (Tokyo) 1989;37(12):3191- 3194.

Lu ZX, Walker KZ, Muir JG, et al. Arabinoxylan fiber, a byproduct of wheat flour processing, reduces the postprandial glucose response in normoglycemic subjects. Am J Clin Nutr 2000;71(5):1123- 1128.

Uyemura K, Tarchiki K, Ghoneum M, et al. MGN- 3, a novel antitumor agent. 92nd Annual Meeting, American Association for Cancer Research 2001;42:24- 28.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

               
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