Generic: zinc sulfate
a minerals and electrolyte - treats Burns, Infertility, Continuous ambulatory peritoneal dialysis, Skin damage caused by incontinence, Muscle cramps, Attention deficit hyperactivity disorder, Exercise performance, Hepatitis C viral infection, Respiratory disease, Tinnitus, Sickle cell anemia, Fungal infections, Psoriasis, Alopecia, Lower respiratory infections in children, Gilbert's syndrome, Closed head injuries, Hepatic encephalopathy, Cystic fibrosis, Dandruff, Anorexia nervosa, Menstrual cramps, Crohn's disease, Kidney function, Cognitive deficits, Diarrhea, Stomatitis, Poisoning, Boils, Liver cirrhosis, Immune function, Pregnancy, Inflammatory bowel disease, Rheumatoid arthritis, Acne vulgaris, High cholesterol, Common cold, Taste perception, Down's syndrome, Hypothyroidism, Kwashiorkor, Blood disorders, Pneumonia, Plaque/ gingivitis, Parasites, Diabetic neuropathy, Malaria, Eczema, Leprosy, Growth, Chronic prostatitis, Trichomoniasis, Zinc deficiency, Diaper rash, Incision wounds, Viral warts, Herpes simplex virus, Mortality, Macular degeneration, Beta-thalassemia, Celiac disease, Bad breath, Leg ulcers, Diabetes, HIV/AIDS, Wilson's disease, Radiation-induced mucositis, Chronic inflammatory rheumatic disease, and Gastric ulcers
SafetyDISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
Case study evidence reports a patient with zinc oxide allergy.
Side Effects and Warnings
Zinc is regarded as a relatively safe and generally well tolerated when taken at recommended doses, and few studies report side effects. Occasionally, adverse effects such as nausea, vomiting, or diarrhea have been observed.
Unpleasant taste, taste distortion, and abdominal cramping have been occasionally reported, especially in studies examining the efficacy of zinc containing lozenges in treating symptoms of common cold or treatment of diarrhea in children. Bleeding gastric erosion, hepatitis (liver inflammation), liver failure, and intestinal bleeding have been reported in individual case reports following the ingestion of higher zinc doses.
Acute tubular necrosis and interstitial nephritis have been reported following the ingestion of large amounts of zinc (doses not specified). Patients with severe kidney disease should reduce or omit taking zinc because it is primarily eliminated in urine.
There is one case report of a fatal outcome from cystic degeneration in putamen and necrosis in the hypothalamus. It was reported as a consequence of zinc treatment for Wilson's disease; however, the patient had received penicillamine, followed by a relatively high dose of zinc per day for several weeks, followed by penicillamine again for an unspecified time so it remains unclear if zinc was responsible for the death.
Slight tingling or burning sensation in the nostril has been reported from zinc nasal gel. A trend toward increased respiratory infections in children has been noted. One case of hypersensitivity pneumonitis has been reported.
Reports of skin conditions have been noted. In one study, worsening of an acne condition was observed following topical application of zinc, although many studies show positive effects of zinc on acne. A case report suggested the presence of dermatitis due to zinc deficiency.
High- quality studies have found evidence of an association between high- dose zinc supplement use and hospitalization for urinary complications, including benign prostatic hyperplasia/ urinary retention, urinary tract infection, and urinary lithiasis. This was especially evident among males.
There is one report of death following the ingestion of 400 coins (mostly pennies). Pennies are composed mostly of zinc. Reduced immune responses have also been observed in a small study.
Pregnancy and Breastfeeding
Pregnancy, Category A: Zinc is categorized as Pregnancy Category A. If this drug is used during pregnancy, the possibility of fetal harm appears remote. Because studies cannot rule out the possibility of harm, however, zinc acetate should only be used during pregnancy if clearly needed. Zinc appears to be safe in amounts that do not exceed the established tolerable upper intake level.
Pregnancy, Category C: Animal reproduction studies have not been conducted with zinc chloride. It is also not known whether zinc chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Zinc chloride should be given to a pregnant woman only if clearly needed under medical supervision.