Generic: Stevia rebaudiana
treats Hyperglycemia and Hypertension
This information is based on a systematic review of scientific literature, and was peer- reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Jill M. Grimes Serrano, PhD (Natural Standard Research Collaboration); Tamara Milkin, PharmD (Northeastern University), Elizabeth A. Poole, PharmD (Drug Information Center, University of Missouri- Kansas City School of Pharmacy); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Northeastern University).
BibliographyDISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
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Chen TH, Chen SC, Chan P, et al. Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. Planta Med 2005;71(2):108- 113.
Ferri LA, Alves- Do- Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res. 2006 Sep;20(9):732- 6.
Gregersen S, Jeppesen PB, Holst JJ, et al. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53(1):73- 76.
Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two- year, randomized, placebo- controlled study. Clin Ther 2003;25(11):2797- 2808.
Koyama E, Kitazawa K, Ohori Y, et al. In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. Food Chem Toxicol 2003;41(3):359- 374.
Maki KC, Curry LL, Carakostas MC, et al. The hemodynamic effects of rebaudioside A in healthy adults with normal and low- normal blood pressure. Food Chem Toxicol 2008;46 Suppl 7:S40- S46.
Mizushina Y, Akihisa T, Ukiya M, et al. Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. Life Sci 9- 9- 2005;77(17):2127- 2140.
Raskovic A, Jakovljevic V, Mikov M, et al. Joint effect of commercial preparations of Stevia rebaudiana Bertoni and sodium monoketocholate on glycemia in mice. Eur J Drug Metab Pharmacokinet. 2004;29(2):83- 86.
Wong KL, Chan P, Yang HY, et al. Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat. Life Sci 3- 26- 2004;74(19):2379- 2387.
Wong KL, Yang HY, Chan P, et al. Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells. Planta Med 2004;70(2):108- 112.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.