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Generic: Salvia divinorum

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This information is based on a systematic review of scientific literature, and was peer- reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Julie Conquer, PhD (RGB Consulting); Sarah Elsabagh, PhD (King's College); Nicole Giese, MS (Natural Standard Research Collaboration); Petra Jancar, PharmD (University of Ljubljan); Rebecca Strauss, PharmD (Northeastern University); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Wendy Weissner, BA (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Ansonoff MA, Zhang J, Czyzyk T, et al. Antinociceptive and Hypothermic Effects of Salvinorin A Are Abolished in a Novel Strain of {kappa}- Opioid Receptor- 1 Knockout Mice. J Pharmacol Exp Ther 2006;318(2):641- 648.

Barnes S, Prasain JK, Wang CC, et al. Applications of LC- MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplements. Life Sci 3- 27- 2006;78(18):2054- 2059.

Beguin C, Richards MR, Li JG, et al. Synthesis and in vitro evaluation of salvinorin A analogues: Effect of configuration at C(2) and substitution at C(18). Bioorg.Med Chem Lett 6- 12- 2006.

Beguin C, Richards MR, Wang Y, et al. Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2). Bioorg.Med Chem Lett 6- 2- 2005;15(11):2761- 2765.

Bertea CM, Luciano P, Bossi S, et al. PCR and PCR- RFLP of the 5S- rRNA- NTS region and salvinorin A analyses for the rapid and unequivocal determination of Salvia divinorum. Phytochemistry 2006;67(4):371- 378.

Bucheler R, Gleiter CH, Schwoerer P, et al. Use of nonprohibited hallucinogenic plants: increasing relevance for public health? A case report and literature review on the consumption of Salvia divinorum (Diviner's Sage). Pharmacopsychiatry 2005;38(1):1- 5.

Capasso R, Borrelli F, Capasso F, et al. The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea- pig ileum. Neurogastroenterol.Motil. 2006;18(1):69- 75.

Carlezon WA Jr., Beguin C, Dinieri JA, et al. Depressive- like effects of the kappa- opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. J Pharmacol Exp Ther 2006;316(1):440- 447.

Fantegrossi WE, Kugle KM, Valdes LJ, et al. Kappa- opioid receptor- mediated effects of the plant- derived hallucinogen, salvinorin A, on inverted screen performance in the mouse. Behav.Pharmacol 2005;16(8):627- 633.

Gonzalez D, Riba J, Bouso JC, et al. Pattern of use and subjective effects of Salvia divinorum among recreational users. Drug Alcohol Depend. 5- 20- 2006.

Harding WW, Schmidt M, Tidgewell K, et al. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A. J Nat Prod. 2006;69(1):107- 112.

Kane BE, Nieto MJ, McCurdy CR, et al. A unique binding epitope for salvinorin A, a non- nitrogenous kappa opioid receptor agonist. FEBS J 2006;273(9):1966- 1974.

McCurdy CR, Sufka KJ, Smith GH, et al. Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist. Pharmacol Biochem Behav. 2006;83(1):109- 113.

Stewart DJ, Fahmy H, Roth BL, et al. Bioisosteric modification of salvinorin A, a potent and selective kappa- opioid receptor agonist. Arzneimittelforschung 2006;56(4):269- 275.

Tidgewell K, Harding WW, Lozama A, et al. Synthesis of salvinorin A analogues as opioid receptor probes. J Nat Prod. 2006;69(6):914- 918.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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