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Safety

DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.

Allergies

Avoid in individuals with a known allergy or hypersensitivity to bulbous buttercup (Ranunculus bulbosus).

Side Effects and Warnings

There are currently a lack of high quality studies on the medicinal applications of bulbous buttercup, and the following adverse effect information is based on traditional use and expert opinion. Bulbous buttercup is very acrid, and application on the skin may cause blisters, swelling, and inflammation of surrounding skin and subcutaneous tissues. Taking bulbous buttercup by mouth may cause vomiting, diarrhea, blistering in the mouth, and abdominal pain. Protoanemonin, a constituent of bulbous buttercup, may also cause ventricular fibrillation (a heart rhythm disorder) and respiratory failure. Bulbous buttercup may also be toxic to the liver if taken by mouth (hepatotoxic), and may cause pleurodynia (pain in the chest). Juice of bulbous buttercup may cause sneezing if applied to the nostrils.

Bulbous buttercup is likely unsafe when used in patients with compromised liver function, cardiovascular conditions, respiratory conditions, diarrhea, vomiting, skin conditions, or gastrointestinal disorders or obstructions.

Pregnancy and Breastfeeding

The use of bulbous buttercup is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

Interactions

Interactions with Drugs

Bulbous buttercup may cause ventricular fibrillation. Patients taking anti- arrhythmic medications should use bulbous buttercup with caution.

Bulbous buttercup may cause vomiting. Caution is advised in patients taking other herbs or supplements that induce vomiting.

Bulbous buttercup may be hepatotoxic (liver damaging). Patients taking medications that may also be liver damaging should consult with a qualified healthcare professional, including a pharmacist.

Protoanemonin, a constituent of bulbous buttercup, may cause respiratory failure at toxic doses. Patients taking bulbous buttercup in combination with other medications with respiratory side effects should use with caution. Consult with a qualified healthcare professional, including a pharmacist, before combining any therapies.

Interactions with Herbs and Dietary Supplements

Bulbous buttercup may cause ventricular fibrillation. Patients taking anti- arrhythmic herbs and supplements should use bulbous buttercup with caution.

Bulbous buttercup may cause vomiting. Caution is advised in patients taking other herbs or supplements that induce vomiting.

Bulbous buttercup may be hepatotoxic (liver damaging). Patients taking herbs or supplements that may also be liver damaging, such as kava, should consult with a qualified healthcare professional, including a pharmacist.

Protoanemonin, a constituent of bulbous buttercup, may cause respiratory failure at toxic doses. Patients taking bulbous buttercup in combination with other herbs and supplements with respiratory side effects should use with caution.

               
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