Drug Compare

Category

Alternate Title

Synonyms

Bisalkaloids, black pepper oil, Brazilian black pepper, dipiperamide D, dipiperamide E, green pepper, pink pepper, Piperaceae (family), piperine, piptigrine, red pepper, white pepper, wisanine.

Note: Black pepper, white pepper, green pepper, pink pepper, and red pepper are all differently preserved berries or seeds of the Piper nigrum plant.

Background

Black pepper (Piper nigrum) is native to India and other southeastern Asian countries. Black pepper, white pepper, green pepper, pink pepper, and red pepper are all differently preserved berries or seeds of the Piper nigrum plant. Although black pepper has been used as a spice for millennia, it has also traditionally been used in India to treat diarrhea. In the Ayurvedic tradition, a preparation called Trikatu (black pepper, long pepper, and ginger) is prescribed routinely for a variety of diseases.

Recent laboratory studies indicate that black pepper may also be beneficial in pain and Alzheimer's disease. In clinical trials, inhalation of black pepper oil improved withdrawal symptoms of cigarette smoking and the ability to swallow in post- stroke patients.

Ingestion of black pepper may cause dyspepsia (upset stomach) and other gastrointestinal adverse effects. Inhalation of black pepper has caused respiratory irritation, edema, and even respiratory arrest, severe anoxia, and death. There may also be a link between ingestion of black pepper and nasopharyngeal or esophageal cancer.

The U.S. Food and Drug Administration (FDA) has approved black pepper, black pepper oil, black pepper oleoresin, piperidine, and piperine as Generally Recognized as Safe (GRAS) for use in foods in the United States.

Evidence

Smoking cessation: Sensory cues associated with cigarette smoking can suppress certain smoking withdrawal symptoms, including the craving for cigarettes. Inhalation of black pepper essential oil may reduce cravings and physical symptoms associated with cigarette smoking withdrawal.
Grade: C

Stroke recovery (difficulty swallowing): Nasal inhalation of volatile black pepper oil in post- stroke patients may improve swallowing dysfunction symptoms. However, more research is needed in this area.
Grade: C