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  • Basic Info
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Generic: Pineapple bromelain
treats Rheumatoid arthritis, Urinary tract infection, Osteoarthritis, Rash, Burn debridement, Nutrition supplementation, Sinusitis, Digestive enzyme/pancreatic insufficiency, Cancer, Steatorrhea, Inflammation, and Chronic obstructive pulmonary disease
               



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Attribution

This information is based on a professional level monograph edited and peer- reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD, MSc, MPhil (Memorial Sloan- Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Cynthia Dacey, PharmD (Northeastern University); Mary McGarry, PharmD (University of Rhode Island); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Mamta Vora, PharmD (Northeastern University); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Natural Standard Research Collaboration).

Bibliography

DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Balakrishnan V, Hareendran A, Nair CS. Double- blind cross- over trial of an enzyme preparation in pancreatic steatorrhoea. J Assoc Physicians India 1981;29(3):207- 209.

Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate- to- severe osteoarthritis of the knee: a randomized placebo- controlled pilot study. QJM. 2006 Dec;99(12):841- 50.

Braun JM, Schneider B, Beuth HJ. Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain- POS in children with acute sinusitis in Germany. In Vivo 2005;19(2):417- 421.

Cirelli MG. Five years of clinical experience with bromelains in therapy of edema and inflammation in postoperative tissue reaction, skin infections and trauma. Clinical Medicine 1967;74(6):55- 59.

Cowie DH, Fairweather DV, Newell DJ. A double- blind trial of bromelains as an adjunct to vaginal plastic repair operations. J Obstet Gynaecol Br Commonw 1970;77(4):365- 368.

Howat RC, Lewis GD. The effect of bromelain therapy on episiotomy wounds- - a double blind controlled clinical trial. J Obstet Gynaecol Br Commonw 1972;79(10):951- 953.

Klein G, Kullich W, Schnitker J, et al. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double- blind, randomised study comparing oral enzymes with non- steroidal anti- inflammatory drugs. Clin Exp Rheumatol 2006 Jan- Feb;24(1):25- 30.

Massimiliano R, Pietro R, Paolo S, et al. Role of bromelain in the treatment of patients with pityriasis lichenoides chronica. J Dermatolog Treat 2007;18(4):219- 22.

Mader H. [Comparative studies on the effect of bromelin and oxyphenbutazone in episiotomy pains]. Schweiz Rundsch.Med Prax 8- 28- 1973;62(35):1064- 1068.

Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19(3):147- 153.

Rosenberg L, Lapid O, Bogdanov- Berezovsky A, et al. Safety and efficacy of a proteolytic enzyme for enzymatic burn debridement: a preliminary report. Burns 2004;30(8):843- 850.

Ryan RE. A double- blind clinical evaluation of bromelains in the treatment of acute sinusitis. Headache 1967;7(1):13- 17.

Seligman B. Oral bromelains as adjuncts in the treatment of acute thrombophlebitis. Angiology 1969;20(1):22- 26.

Seltzer AP. Adjunctive use of bromelains in sinusitis: a controlled study. Eye Ear Nose Throat Mon 1967;46(10):1281, 1284, 1286- 1288.

Weiss S, Scherrer M. [Crossed double- blind trial of potassium iodide and bromelain (Traumanase) in chronic bronchitis]. Schweiz Rundsch Med Prax 10- 24- 1972;61(43):1331- 1333.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

               
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