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  • Basic Info
Licensed from
Generic: Pc-Spes
treats Prostate cancer
               



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Interactions

Interactions with Drugs

Based on reported cases of bleeding and inclusion of undeclared amounts of the prescription blood- thinner warfarin in some samples, PC- SPES® may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti- platelet drugs such as clopidogrel (Plavix®), and non- steroidal anti- inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®). In contrast, PC- SPES® has also been associated with an increased risk of blood clots, which may be due to estrogen- like effects. This would work against the action of blood- thinning medications.

Based on the proposed anti- androgenic mechanism of action of saw palmetto, a major ingredient of PC- SPES®, additive effects may occur with anti- androgen drugs such as the 5α- reductase inhibitor finasteride (Proscar®); the androgen receptor antagonists bicalutamide (Casodex®), flutamide (Eulexin®), and nilutamide (Nilandron®); or the GnRH antagonists leuprolide (Lupron®), goserelin (Zoladex®), and histrelin (Supprelin®). Similarly, this therapy may decrease the effectiveness of therapeutic androgens such as testosterone (Androderm®, Testoderm®), methyltestosterone (Android®, Testred®, Virilon®), fluoxymesterone (Halotestin®), nandrolone decanoate (Deca- Dubrolin®), or stanozolol (Winstrol®).

PC- SPES® may add to the estrogenic effects of other drugs, based on estrogen- like effects reported in studies, and the presence of undeclared amounts of prescription estrogen drugs in some samples of PC- SPES®.

PC- SPES® may interfere with certain chemotherapy drugs like paclitaxel. PC- SPES® may affect the way the liver breaks down certain drugs.

Interactions with Herbs and Dietary Supplements

Based on reported cases of bleeding and inclusion of undeclared amounts of the prescription blood- thinner warfarin in some samples, PC- SPES® may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases. In contrast, PC- SPES® has also been associated with an increased risk of blood clots, which may be due to estrogen- like effects. This would work against the action of blood- thinning agents.

PC- SPES® may add to the estrogenic effects of other agents based on estrogen- like effects reported in studies and the presence of undeclared amounts of prescription estrogen drugs in some samples.

PC- SPES® may affect the way the liver breaks down certain herbs and supplements.

               
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