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Generic: Mugwort
               



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Interactions

Interactions with Drugs

Mugwort contains coumarin derivatives, which may increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti- platelet drugs such as clopidogrel (Plavix®), and non- steroidal anti- inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Interactions with Herbs and Dietary Supplements

Mugwort contains coumarin derivatives, which may increase the risk of bleeding. Caution is advised in patients with bleeding disorders or taking herbs that may increase the risk of bleeding. Dosing adjustments may be necessary.

Attribution

This information is based on a systematic review of scientific literature, and was peer- reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Nicole Giese, MS (Natural Standard Research Collaboration); Catherine DeFranco Kirkwood, MPH, CCCJS- MAC (MD Anderson Cancer Center); Adam McLean, MPharm (University of Nottingham); Erica Seamon, PharmD (Nova Southeastern University); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Chris Tonelli, MA (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Shannon Welch, PharmD (Northeastern University); Lisa Wendt, PharmD (Albany College of Pharmacy).

Bibliography

DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Bauer R, Himly M, Dedic A, et al. Optimization of codon usage is required for effective genetic immunization against Art v 1, the major allergen of mugwort pollen. Allergy 2003;58(10):1003- 1010.

Darsow U, Vieluf D, Ring J. Evaluating the relevance of aeroallergen sensitization in atopic eczema with the atopy patch test: a randomized, double- blind multicenter study. Atopy Patch Test Study Group. J Am Acad Dermatol. 1999;40(2 Pt 1):187- 193.

Figueroa J, Blanco C, Dumpierrez AG, et al. Mustard allergy confirmed by double- blind placebo- controlled food challenges: clinical features and cross- reactivity with mugwort pollen and plant- derived foods. Allergy 2005;60(1):48- 55.

Gilani AH, Yaeesh S, Jamal Q, et al. Hepatoprotective activity of aqueous- methanol extract of Artemisia vulgaris. Phytother Res 2005;19(2):170- 172.

Jimeno, L., Duffort, O., Serrano, C., et al. Monoclonal antibody- based ELISA to quantify the major allergen of Artemisia vulgaris pollen, Art v 1. Allergy 2004;59(9):995- 1001.

Kurzen M, Bayerl C, Goerdt S. [Occupational allergy to mugwort]. J Dtsch Dermatol.Ges. 2003;1(4):285- 290.

Osterballe M, Hansen TK, Mortz CG, et al. The clinical relevance of sensitization to pollen- related fruits and vegetables in unselected pollen- sensitized adults. Allergy 2005;60(2):218- 225.

Palacin A, Cumplido J, Figueroa J, et al. Cabbage lipid transfer protein Bra o 3 is a major allergen responsible for cross- reactivity between plant foods and pollens. J Allergy Clin Immunol 2006;117(6):1423- 1429.

Ramezani M, Fazli- Bazzaz BS, Saghafi- Khadem F, et al. Antimicrobial activity of four Artemisia species of Iran. Fitoterapia 2004;75(2):201- 203.

Rossi RE, Monasterolo G. A pilot study of feasibility of ultra- rush (20- 25 minutes) sublingual- swallow immunotherapy in 679 patients (699 sessions) with allergic rhinitis and/ or asthma. Int J Immunopathol.Pharmacol 2005;18(2):277- 285.

Sakagami H, Matsumoto H, Satoh K, et al. Cytotoxicity and radical modulating activity of Moxa smoke. In Vivo 2005;19(2):391- 397.

Schmid- Grendelmeier P, Holzmann D, Himly M, et al. Native Art v 1 and recombinant Art v 1 are able to induce humoral and T cell- mediated in vitro and in vivo responses in mugwort allergy. J.Allergy Clin.Immunol. 2003;111(6):1328- 1336.

Tuekpe MK, Todoriki H, Sasaki S, et al. Potassium excretion in healthy Japanese women was increased by a dietary intervention utilizing home- parcel delivery of Okinawan vegetables. Hypertens.Res 2006;29(6):389- 396.

Vermeulen AM, Groenewoud GC, de Jong NW, et al. Primary sensitization to sweet bell pepper pollen in greenhouse workers with occupational allergy. Clin Exp Allergy 2003;33(10):1439- 1442.

Wopfner N, Gadermaier G, Egger M, et al. The spectrum of allergens in ragweed and mugwort pollen. Int Arch Allergy Immunol. 2005;138(4):337- 346.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

               
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