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  • Basic Info
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Generic: Hydrazine sulfate
treats Cachexia and Cancer treatment
               



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Category

Herbs & Supplements

Synonyms

2,4- dinitro- phenylhydrazine, alpha- methyldopa- hydrazine, beta- phenylisopropylhydrazine, carbidopa, diamide, diamine, dimethylhydrazine, hydrazine, hydrazine monosulphate, hydrazine sulphate, hydrazinium sulphate, hydrazonium sulphate, idrazina solfato (Italian), Sehydrin®.

Background

Cachexia is defined as physical wasting with loss of weight and muscle mass caused by disease. Patients with advanced cancer, AIDS, and some other major chronic progressive diseases may appear cachectic. Anorexia (lack of appetite) and cachexia often occur together. Cachexia can occur in people who are eating enough, but who cannot absorb the nutrients. Cachexia is not the same as starvation. A healthy person's body can adjust to starvation by slowing down its use of nutrients, but in cachectic patients, the body does not make this adjustment.

Hydrazine is an industrial chemical marketed as having the potential to repress weight loss and cachexia associated with cancer and to improve general appetite status. However, in large randomized controlled trials, hydrazine has not been proven effective for improving appetite, reducing weight loss, or improving survival in adults with small cell lung cancer (when used as adjuvant therapy) or metastatic colorectal cancer (when used alone).

Hydrazine sulfate causes liver damage in rodents. It is associated with nausea and vomiting, fatigue, sensory and motor neuropathies, and a significantly reduced quality of life in cancer patients. It is currently being investigated as a potential treatment for endotoxin- mediated shock. Hydrazine sulfate has demonstrated significant mutagenic and carcinogenic potential in animal studies.

Hydrazine has not been well evaluated for safety or toxicity during pregnancy, lactation, or childhood.

Other applications of hydrazine include: corrosion inhibitor, herbicide and pesticide component, laboratory reagent, refining rare metals, soldering flux for light metals, silvering of mirrors, and rocket fuel.

               
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