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  • Basic Info
Licensed from
Generic: Gynostemma pentaphyllum
treats Fatty liver and Cancer
               



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Dosing

Adults (18 years and older):

There is no proven effective dose for jiaogulan, although 80 milliliters of Gynostemma pentaphyllum extraction has been taken for four months in conjunction with a controlled diet for fatty liver.

Children (younger than 18 years):

There is no proven safe or effective dose for jiaogulan in children.

Safety

DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.

Allergies

Avoid in individuals with a known allergy or hypersensitivity to jiaogulan (Gynostemma pentaphyllum) or its constituents.

Side Effects and Warnings

Currently, there is not enough available evidence about the side effects of jiaogulan. Nonetheless, use cautiously in patients with hematologic (blood) conditions or taking anticoagulants or anti- platelet agents (blood thinners). Also, use cautiously in patients with diabetes as Gynostemma pentaphyllum may decrease insulin levels and insulin index scores.

Pregnancy and Breastfeeding

Jiaogulan is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

Interactions

Interactions with Drugs

Although not well studied in humans, gypenosides extracted from Gynostemma pentaphyllum may have anticancer effects. Caution is advised when taking jiaogulan with other anticancer agents.

Gynostemma pentaphyllum may decrease serum triglyceride levels. Thus, caution is advised when combining jiaogulan with other cholesterol- lowering agents.

Gynostemma pentaphyllum may inhibit nuclear factor- kappaB activation, an important inflammatory factor. Caution is advised in patients taking anti- inflammatory agents.

Gynostemma pentaphyllum may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. However, current evidence is mixed. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti- platelet drugs such as clopidogrel (Plavix®), and non- steroidal anti- inflammatory drugs (NSAIDS) such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Gynostemma pentaphyllum may decrease alanine aminotransferase, alkaline phosphatase, or aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease. Caution is advised when combining jiaogulan with any potentially liver- damaging (hepatotoxic) agents.

Gynostemma pentaphyllum may decrease insulin levels and insulin index scores in patients with nonalcoholic fatty liver disease. Caution is advised when combining jiaogulan with diabetes agents.

Interactions with Herbs and Dietary Supplements

Although not well studied in humans, gypenosides extracted from Gynostemma pentaphyllum may have anticancer effects. Caution is advised when taking jiaogulan with other herbs or supplements that have potential anticancer effects.

Gynostemma pentaphyllum may decrease serum triglyceride levels. Thus, caution is advised when combining jiaogulan with other cholesterol- lowering herbs or supplements, such as red yeast rice.

Gynostemma pentaphyllum may inhibit nuclear factor- kappaB activation, an important inflammatory factor. Caution is advised in patients taking anti- inflammatory herbs or supplements.

Gynostemma pentaphyllum may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. However, current evidence is mixed. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Gynostemma pentaphyllum may decrease alanine aminotransferase, alkaline phosphatase, or aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease. Caution is advised when combining jiaogulan with any potentially liver- damaging (hepatotoxic) herbs or supplements.

Gynostemma pentaphyllum may decrease insulin levels and insulin index scores in patients with nonalcoholic fatty liver disease. Caution is advised when combining jiaogulan with herbs or supplements taken to control blood sugar.

               
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