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  • Basic Info
Licensed from
Generic: Gynostemma pentaphyllum
treats Fatty liver and Cancer

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This information is based on a systematic review of scientific literature, and was peer- reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): J. Kathryn Bryan, BA (Natural Standard Research Collaboration); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Chen JC, Chung JG, Chen LD. Gypenoside induces apoptosis in human Hep3B and HA22T tumour cells. Cytobios 1999;100(393):37- 48.

Chen JC, Lu KW, Lee JH, et al. Gypenosides induced apoptosis in human colon cancer cells through the mitochondria- dependent pathways and activation of caspase- 3. Anticancer Res 2006;26(6B):4313- 4326.

Chou SC, Chen KW, Hwang JS, et al. The add- on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease. Altern Ther Health Med 2006;12(3):34- 39.

Han MQ, Liu JX, Gao H. [Effects of 24 Chinese medicinal herbs on nucleic acid, protein and cell cycle of human lung adenocarcinoma cell]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(3):147- 149.

Hou J, Liu S, Ma Z, et al. Effects of gynostemma pentaphyllum makino on the immunological function of cancer patients. J.Tradit.Chin Med. 1991;11(1):47- 52.

Huang TH, Li Y, Razmovski- Naumovski V, et al. Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor- kappaB activation via a PPAR- alpha- dependent pathway. J Biomed Sci 2006;13(4):535- 548.

Huang TH, Razmovski- Naumovski V, Salam NK, et al. A novel LXR- alpha activator identified from the natural product Gynostemma pentaphyllum. Biochem Pharmacol 11- 1- 2005;70(9):1298- 1308.

Liu X, Ye W, Mo Z, et al. Three dammarane- type saponins from Gynostemma pentaphyllum. Planta Med 2005;71(9):880- 884.

Takagi J, Imada T, Kikuchi T, et al. A new platelet aggregation factor from Gynostemma pentaphyllum Makino. Chem.Pharm.Bull.(Tokyo) 1985;33(12):5568- 5571.

Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(5):278- 80, 261.

Wang C, Zhao X, Mao S, et al. Management of SAH with traditional Chinese medicine in China. Neurol.Res 2006;28(4):436- 444.

Wang QF, Chen JC, Hsieh SJ, et al. Regulation of Bcl- 2 family molecules and activation of caspase cascade involved in gypenosides- induced apoptosis in human hepatoma cells. Cancer Lett 9- 26- 2002;183(2):169- 178.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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