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  • Basic Info
Licensed from
Generic: Guggul
treats Obesity, Rheumatoid arthritis, Osteoarthritis, Acne, and Hypercholesterolemia
               



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Interactions

Interactions with Drugs

Co- administration of guggulipid to humans has been reported to decrease the bioavailability of the beta- blocker propranolol and the calcium channel blocker diltiazem.

Gugulipid has been associated with inhibition of platelets and increased blood clot breakdown. In theory, guggul may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti- platelet drugs such as clopidogel (Plavix®), and non- steroidal anti- inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

The effect of guggul on serum lipids remains controversial. Guggul may affect serum lipid levels (decreasing cholesterol, triglycerides, and low- density lipoproteins; increasing high- density lipoproteins), and may thus increase the effects of lipid- lowering drugs such as statins.

Animal studies suggest that the guggul constituent Z- guggulsterone may stimulate thyroid function. Therefore, additional effects may occur in patients taking thyroid drugs and guggul together.

Interactions with Herbs and Dietary Supplements:

The effect of guggul on serum lipids remains controversial. Guggul may affect serum lipid levels (decreasing cholesterol, triglycerides, and low- density lipoproteins; increasing high- density lipoproteins), and may thus increase the lipid- lowering effects of lipid- lowering agents such as niacin, garlic, or fish oil (omega- 3 fatty acids).

Gugulipid has been associated with inhibition of platelets and increased blood clot breakdown. In theory, guggul may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic or saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

               
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