treats Laxative/bowel preparation for procedures, Burns, Exercise performance, Hypercalcemia, Bone density, Total parenteral nutrition, Refeeding syndrome prevention, Vitamin D resistant rickets, Kidney stones, Diabetic ketoacidosis, Hyperparathyroidism, Constipation, Hypercalciuria, and Hypophosphatemia
Interactions with Drugs
Bile acid sequestrants such as cholestyramine (Questran®) and colestipol (Colestid®) can decrease oral absorption of phosphate. Therefore, oral phosphate supplements should be administered at least one hour before or four hours after these agents.
Corticosteroids may increase urinary phosphorus levels.
Alcohol (ethanol) may increase urinary phosphorus. Wine may enhance absorption of phosphorus (as well as calcium and magnesium).
Medications that may affect electrolyte levels should be used cautiously with phosphates. Examples include: amiloride (Midamor®); angiotensin- converting enzyme (ACE) inhibitors such as benazepril (Lotensin®), captopril (Capoten®), enalapril (Vasotec®), fosinopril (Monopril®), lisinopril (Zestril®, Prinivil®), quinapril (Accupril®), or ramipril (Altace®); cyclosporine; cardiac glycosides (Digoxin®); heparins; anti- inflammatory drugs; potassium- containing agents; salt substitutes; spironolactone (Aldactone®); and triamterene (Dyrenium®).
Interactions with Herbs and Dietary Supplements
Calcium may impair phosphates in the body, and result in calcium deposits in tissues.
Pumpkin seed may increase urine phosphates.
This information is based on a systematic review of scientific literature, edited and peer- reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD, MSc, MPhil (Memorial Sloan Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Cynthia Dacey, PharmD (Northeastern University); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Christine Ulbricht, BS (University of Massachusetts); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Natural Standard Research Collaboration).