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  • Basic Info
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Generic: Phosphorus
treats Laxative/bowel preparation for procedures, Burns, Exercise performance, Hypercalcemia, Bone density, Total parenteral nutrition, Refeeding syndrome prevention, Vitamin D resistant rickets, Kidney stones, Diabetic ketoacidosis, Hyperparathyroidism, Constipation, Hypercalciuria, and Hypophosphatemia
               



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Interactions

Interactions with Drugs

Antacids containing aluminum, calcium, or magnesium can bind phosphate in the gut and prevent its absorption, potentially leading to hypophosphatemia (low phosphate levels) when used chronically.

Some anticonvulsants (including phenobarbital and carbamazepine) may lower phosphorus levels and increase levels of alkaline phosphatase.

Bile acid sequestrants such as cholestyramine (Questran®) and colestipol (Colestid®) can decrease oral absorption of phosphate. Therefore, oral phosphate supplements should be administered at least one hour before or four hours after these agents.

Corticosteroids may increase urinary phosphorus levels.

Potassium supplements or potassium- sparing diuretics taken together with a phosphate may result in high blood levels of potassium (hyperkalemia).

Alcohol (ethanol) may increase urinary phosphorus. Wine may enhance absorption of phosphorus (as well as calcium and magnesium).

Medications that may affect electrolyte levels should be used cautiously with phosphates. Examples include: amiloride (Midamor®); angiotensin- converting enzyme (ACE) inhibitors such as benazepril (Lotensin®), captopril (Capoten®), enalapril (Vasotec®), fosinopril (Monopril®), lisinopril (Zestril®, Prinivil®), quinapril (Accupril®), or ramipril (Altace®); cyclosporine; cardiac glycosides (Digoxin®); heparins; anti- inflammatory drugs; potassium- containing agents; salt substitutes; spironolactone (Aldactone®); and triamterene (Dyrenium®).

Interactions with Herbs and Dietary Supplements

Calcium may impair phosphates in the body, and result in calcium deposits in tissues.

Pumpkin seed may increase urine phosphates.

Excessive doses of calcitriol, the active form of vitamin D (or its analogs) may result in hyperphosphatemia (high phosphate levels).

Attribution

This information is based on a systematic review of scientific literature, edited and peer- reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD, MSc, MPhil (Memorial Sloan Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Cynthia Dacey, PharmD (Northeastern University); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Christine Ulbricht, BS (University of Massachusetts); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Natural Standard Research Collaboration).

               
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