treats Leukemia, Non-small cell lung cancer, Nasopharyngeal carcinoma, Esophageal cancer, Liver cancer, Colorectal cancer, Breast cancer, Gastric cancer, and Lung cancer
TraditionWARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Adults (over 18 years old)
Safety and efficacy has not been proven for any dose. When taken by mouth, 3 grams of PSK has been used daily or every other day, either alone or with conventional therapy. 1 gram, three times daily of PSK for one month, has been used for the treatment of a tumor. PSK has also been administered at a dose of 2- 3 grams/ meter2 daily in three divided doses for one month.
Children (under 18 years old)
There is not enough evidence available to recommend the use of PSK in children.
SafetyDISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
Avoid in individuals with a known allergy/ hypersensitivity to PSK, Coriolus versicolor, or any of its constituents.
Side Effects and Warnings
PSK generally seems to have a low incidence of mild and tolerable side effects. In one report, three cases of toxicity were noted, and PSK was discontinued. PSK has been associated with side effects of gastrointestinal upset and darkening of the fingernails, but these effects have been limited and general safety has been demonstrated with daily oral doses for extended periods. Darkening of the fingernails and coughing have been reported during the administration of the powder drug.
Low blood cell counts including leukopenia, thrombocytopenia, and albuminuria (protein in the urine) were observed in two clinical trials. It should be noted that patients also received chemotherapy in addition to PSK in these trials, which may have contributed.
Use cautiously in patients with coronary artery disease due to antiangiogenic properties (inhibition of new blood vessel growth) in the heart.
Pregnancy and Breastfeeding
Not recommended due to lack of sufficient data.