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  • Basic Info
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Generic: Citrus aurantium
treats Fungal infections, Aging, Weight loss, and Dementia

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This information is based on a systematic review of scientific literature, and was peer- reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Linda Poon, PharmD (Northeastern University); Erica Seamon, PharmD (Nova Southeastern University); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Bent S, Padula A, Neuhaus J. Safety and efficacy of citrus aurantium for weight loss. Am J Cardiol 11- 15- 2004;94(10):1359- 1361.

Bouchard NC, Howland MA, Greller HA, et al. Ischemic stroke associated with use of an ephedra- free dietary supplement containing synephrine. Mayo Clin Proc 2005;80(4):541- 545.

Bui LT, Nguyen DT, Ambrose PJ. Blood pressure and heart rate effects following a single dose of bitter orange. Ann Pharmacother 2006;40(1):53- 57.

Fang F, Dong M, Zhu H. [Effect of Citrus aurantium extract on L- type calcium currents in ventricular myocytes of single guinea pigs]. Hunan Yi Ke Da Xue.Xue Bao. 2003;28(4):353- 356.

Firenzuoli F, Gori L, Galapai C. Adverse reaction to an adrenergic herbal extract (Citrus aurantium). Phytomedicine 2005;12(3):247- 248.

Fugh- Berman A, Myers A. Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research. Exp Biol Med (Maywood.) 2004;229(8):698- 704.

Gougeon R, Harrigan K, Tremblay JF, et al. Increase in the thermic effect of food in women by adrenergic amines extracted from citrus aurantium. Obes Res 2005;13(7):1187- 1194.

Gray S, Woolf AD. Citrus aurantium used for weight loss by an adolescent with anorexia nervosa. J Adolesc.Health 2005;37(5):414- 415.

Haller CA, Benowitz NL, Jacob P III. Hemodynamic effects of ephedra- free weight- loss supplements in humans. Am J Med 2005;118(9):998- 1003.

Hosseinimehr SJ, Karami M. Citrus extract modulates genotoxicity induced by cyclophosphamide in mice bone marrow cells. J Pharm Pharmacol 2005;57(4):505- 509.

Hosseinimehr SJ, Tavakoli H, Pourheidari G, et al. Radioprotective effects of citrus extract against gamma- irradiation in mouse bone marrow cells. J Radiat Res (Tokyo) 2003;44(3):237- 241.

Martin KW, Ernst E. Herbal medicines for treatment of fungal infections: a systematic review of controlled clinical trials. Mycoses 2004;47(3- 4):87- 92.

McBride BF, Karapanos AK, Krudysz A, et al. Electrocardiographic and hemodynamic effects of a multicomponent dietary supplement containing ephedra and caffeine: a randomized controlled trial. JAMA 1- 14- 2004;291(2):216- 221.

Nasir JM, Durning SJ, Ferguson M, et al. Exercise- induced syncope associated with QT prolongation and ephedra- free Xenadrine. Mayo Clin Proc 2004;79(8):1059- 1062.

Nykamp DL, Fackih MN, Compton AL. Possible association of acute lateral- wall myocardial infarction and bitter orange supplement. Ann Pharmacother 2004;38(5):812- 816.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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