Generic: Citrus aurantium
treats Fungal infections, Aging, Weight loss, and Dementia
Adults (18 years and older)
There is no proven safe or effective dose for bitter orange as a medicinal agent. However, bitter orange has generally recognized as safe (GRAS) status for the use in foods in the United States.
Children (younger than 18 years)
There is no proven safe or effective dose for bitter orange in children.
SafetyDISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
Avoid in individuals with a known allergy or hypersensitivity to bitter orange or the Rutaceae family.
Side Effects and Warnings
Bitter orange has generally recognized as safe (GRAS) status for the use in foods in the United States. Despite the lack of systematic study on the safety and efficacy of bitter orange, there are several theoretical side effects that may occur from the use of bitter orange. For instance, bitter orange may cause adverse cardiovascular effects in otherwise healthy individuals; avoid in patients with preexisting cardiovascular (heart) disease. Theoretically, bitter orange may worsen narrow- angle glaucoma. It may also trigger migraine or cluster headaches. Use cautiously in patients with hyperthyroidism (overactive thyroid gland). Bitter orange may worsen the condition due to its synephrine content.
Due to its potential photosensitizing effects, use topical bitter orange preparations cautiously in patients with fair skin.
Avoid using in patients with intestinal colic based on reports of convulsion and death in children who consume large amounts of bitter orange peel. Also avoid using in patients taking QT- interval prolonging drugs or with long QT interval syndrome. Theoretically, bitter orange might increase the risk of ventricular arrhythmias (irregular heart rhythms).
Pregnancy and Breastfeeding