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  • Basic Info
Licensed from
Generic: Citrus aurantium
treats Fungal infections, Aging, Weight loss, and Dementia
               



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Interactions

Interactions with Drugs

Theoretically, bitter orange might be antagonized by alpha blocking agents. Caution is advised.

Theoretically, concomitant use of bitter orange and beta blockers might cause acute hypertension (high blood pressure).

Large amounts of caffeine might increase the risk of hypertension and adverse cardiovascular effects with bitter orange due to synephrine content.

Theoretically, concurrent use of monoamine oxidase inhibitors (MAOIs) with synephrine- containing bitter orange preparations might increase the blood pressure raising effects of synephrine and potentially cause hypertensive crisis. Bitter orange contains tyramine, octopamine, and synephrine, which are MAO substrates. Caution is advised when taking bitter orange with other MAOIs.

Bitter orange juice may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be decreased in the blood, and reduce the intended effects. Patients taking any medications should check the package insert and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.

Oil of bergamot, which comes from Citrus aurantium ssp. Bergamia, may cause hyperpigmentation, dermatitis or make a patient more sensitive to laser treatment. Caution is advised when taking bitter orange with other photosensitizing agents.

Bitter orange might prolong the QT interval in some patients, especially when in combination with other stimulants such as caffeine. Theoretically, bitter orange could have an additive effect when combined with drugs that prolong the QT interval and potentially increase the risk of ventricular arrhythmias (irregular heart beats). Use of bitter orange with other cardioactive agents may also increase this risk.

Theoretically, drugs with central nervous system (CNS) stimulant properties, such as phenylpropanolamine and pseudoephedrine, might increase the risk of hypertension and adverse cardiovascular effects of bitter orange due to synephrine content.

Theoretically, bitter orange may interact with thyroid medications, or worsen hyperthyroidism due to its synephrine content.

Interactions with Herbs and Dietary Supplements

Theoretically, anti- adrenergic herbs or supplements might antagonize bitter orange. Caution is advised.

Honey reduces the absorption of naringin, a flavone glycoside of bitter orange.

Theoretically, concurrent use of herbs with monoamine oxidase inhibitor activity with synephrine- containing bitter orange preparations might increase the blood pressure raising effects of synephrine and potentially cause hypertensive crisis. Bitter orange contains tyramine, octopamine, and synephrine, which are MAO substrates. Caution is advised when taking bitter orange with other herbs with MAOI effects.

Bitter orange may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may become too high in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system.

Theoretically, Panax ginseng might prolong the QT interval on electrocardiogram (ECG). Thus, combining Panax ginseng and bitter orange might have an additive effect on the QT interval and increase the risk for arrhythmias (irregular heart beats). Use of bitter orange with other cardioactive herbs or supplements may also increase this risk.

Oil of bergamot, which comes from Citrus aurantium ssp. Bergamia, may cause hyperpigmentation, dermatitis or make a patient more sensitive to laser treatment. Caution is advised when taking bitter orange with other photosensitizing herbs.

Theoretically, herbs and supplements with stimulant properties, such as ephedra, guarana, and mate, might increase the risk of hypertension (high blood pressure) and adverse cardiovascular effects with bitter orange due to synephrine content.

Theoretically, bitter orange may interact with herbs affecting the thyroid, or worsen hyperthyroidism due to its synephrine content.

               
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