Interactions

Interactions with Drugs

Modified citrus pectin may significantly increase the urinary excretion of metals. Caution is advised in patients taking chelating agents.

Although not well studied in humans, pectin may lower cholesterol levels. Consult with a qualified healthcare professional, including a pharmacist, before combining modified citrus pectin with cholesterol- lowering agents.

Based on animal study, modified citrus pectin may significantly inhibit carbohydrate- mediated tumor growth. Patients taking any agents for cancer should use modified citrus pectin with caution.

Modified citrus pectin may slow or reduce the absorption of oral drugs. Caution is advised when taking medications by mouth.

Interactions with Herbs and Dietary Supplements

Modified citrus pectin may significantly increase the urinary excretion of metals. Caution is advised in patients taking chelating agents.

Although not well studied in humans, pectin may lower cholesterol levels. Consult with a qualified healthcare professional, including a pharmacist, before combining modified citrus pectin with cholesterol- lowering agents.

Although not well studied in humans, modified citrus pectin may significantly inhibit carbohydrate- mediated tumor growth. Patients taking any herbs or supplements for cancer should use modified citrus pectin with caution.

Modified citrus pectin may slow or reduce the absorption of oral agents. Caution is advised when taking herbs and supplements by mouth.

Attribution

This information is based on a systematic review of scientific literature, and was peer- reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD, MSc, MPhil (Memorial Sloan- Kettering Cancer Center); J. Kathryn Bryan, BA (Natural Standard Research Collaboration); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).

Bibliography

Bresalier RS, Yan PS, Byrd JC, et al. Expression of the endogenous galactose- binding protein galectin- 3 correlates with the malignant potential of tumors in the central nervous system. Cancer 8- 15- 1997;80(4):776- 787.

Eastwood M, Kritchevsky D. Dietary fiber: how did we get where we are? Annu Rev Nutr 2005;25:1- 8.

Eliaz I, Hotchkiss AT, Fishman ML, et al. The effect of modified citrus pectin on urinary excretion of toxic elements. Phytother Res 2006;20(10):859- 864.

Guess BW, Scholz MC, Strum SB, et al. Modified citrus pectin (MCP) increases the prostate- specific antigen doubling time in men with prostate cancer: a phase II pilot study. Prostate Cancer Prostatic Dis 2003;6(4):301- 304.

Hayashi A, Gillen AC, Lott JR. Effects of daily oral administration of quercetin chalcone and modified citrus pectin on implanted colon- 25 tumor growth in Balb- c mice. Altern Med Rev 2000;5(6):546- 552.

Hsieh TC, Wu JM. Changes in cell growth, cyclin/ kinase, endogenous phosphoproteins and nm23 gene expression in human prostatic JCA- 1 cells treated with modified citrus pectin. Biochem Mol Biol Int 1995;37(5):833- 841.

Kidd P. A new approach to metastatic cancer prevention: modified citrus pectin (MCP), a unique pectin that blocks cell surface lectins. Altern Med Rev 1996;1:4- 10.

Marounek M, Volek Z, Synytsya A, et al. Effect of pectin and amidated pectin on cholesterol homeostasis and caecal metabolism in rats fed a high- cholesterol diet. Physiol Res 2007;56(4):433- 42.

Modified citrus pectin- monograph. Altern Med Rev 2000;5(6):573- 575.

Nangia- Makker P, Hogan V, Honjo Y, et al. Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. J Natl Cancer Inst 12- 18- 2002;94(24):1854- 1862.

Pienta KJ, Naik H, Akhtar A, et al. Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. J Natl.Cancer Inst 3- 1- 1995;87(5):348- 353.

Raz A, Loton R. Endogenous galactoside- binding lectins: a new class of functional cell surface molecules related to metastasis. Cancer Metastasis Rev 1987;6:433- 452.

Strum S, Scholz M, McDermed J, et al. Modified citrus pectin slows PSA doubling time: A pilot clinical trial. Presentation: International Conference on Diet and Prevention of Cancer. May 28, 1999 - June 2, 1999.

Terpstra AH, Lapre JA, de Vries HT, et al. The hypocholesterolemic effect of lemon peels, lemon pectin, and the waste stream material of lemon peels in hybrid F1B hamsters. Eur J Nutr 2002;41(1):19- 26.

Vergara- Jimenez M, Furr H, Fernandez ML. Pectin and psyllium decrease the susceptibility of LDL to oxidation in guinea pigs. J Nutr Biochem 1999;10(2):118- 124.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.