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  • Basic Info
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Generic: Catha edulis
treats Cognitive function
               



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Interactions

Interactions with Drugs

Use khat cautiously in patients taking amoxicillin or ampicillin. Khat may reduce the effectiveness of these drugs. These two antibiotics, particularly ampicillin, should be taken two hours after khat chewing.

Sympathomimetic effects of khat such as mydriasis (dilation of the pupil) and hypertension (high blood pressure) may be antagonized by antiadrenergic drugs including clonidine, reserpine, or terazosin.

Theoretically, khat may antagonize the effects of heart medications or blood pressure lowering agents. Khat has been reported to cause an increase in systolic and diastolic blood pressure and heart rate.

Use cautiously in patients taking beta- blockers or tricyclic antidepressants. Theoretically, khat may increase the risk of cardiovascular side effects with these drugs.

Khat may cause central nervous system (CNS) stimulation and use with other CNS stimulants may lead to additive effects. Stimulant and amphetamine- like effects are likely due to the phenylalkylamine alkaloid cathinone.

Theoretically, concurrent use of khat with monoamine oxidase inhibitors may cause hypertensive (high blood pressure) crisis.

Interactions with Herbs & Dietary Supplements

Khat may antagonize the effects of antihypertensive (blood pressure lowering) herbs and supplements. Khat has been reported to cause an increase in systolic and diastolic blood pressure and heart rate. Caution is advised.

Theoretically, concurrent use of khat with herbs with monoamine oxidase inhibitor- like activity may cause hypertensive (high blood pressure) crisis.

Theoretically, khat may increase the stimulant effects if taken with stimulant herbs and supplements, such as guarana or ephedra.

Attribution

This information is based on a systematic review of scientific literature, and was peer- reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Erica Seamon, PharmD (Nova Southeastern University); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Shannon Welch, PharmD (Northeastern University).

               
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