treats Allergic rhinitis prevention, Migraine prophylaxis, Allergic skin disease, and Asthma
TraditionWARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Antispasmodic, anxiety, appetite stimulant, cardiovascular conditions, chills, chronic cough, colds, cramps, diuretic (increases urine flow), fever, gastric ulcers, headache treatment, indigestion, insomnia, irritable bladder, ocular allergy, pain, plague, urinary complaints, urinary tract spasm, whooping cough, wound/ skin healing.
Adults (18 years and older)
Studies have reported safety and good tolerability of commercially available butterbur products (which are free of potentially carcinogenic pyrrolizidine alkaloid constituents), when used orally in recommended doses for up to 12- 16 weeks.
For allergic rhinitis, 50 milligrams of standardized butterbur (Petadolex®, standardized to contain 7.5 milligrams of petasin and isopetasin per 50- milligrams tablet) has been used twice daily. A large study used one tablet of carbon dioxide extract standardized to 8.0 milligrams of total petasin per tablet (Tesalin®), taken four times daily, while a smaller study reported that 2 standardized tablets taken three times daily was effective.
Dosing for asthma is undefined due to a lack of evidence. However, 50 milligrams of standardized butterbur (Petaforce®), administered in two divided daily doses, in patients maintained on inhaled corticosteroids has been used. Petadolex® 150 milligrams daily in three divided daily doses for 2- 4 months has also been studied.
For migraine prophylaxis, 50- 75 milligrams Petadolex® twice daily for up to four months has been studied. One study suggested that the 75- milligram dose but not the 50- milligram dose is effective.
Children (younger than 18 years)
For asthma, 50- 150 milligrams daily (depending on age) of a pyrrolizidine- free butterbur rhizome extract standardized to 7.5 milligrams of petasin and isopetasin per 50- milligram tablet (Petadolex®) may be effective. However, due to a lack of safety and efficacy data, butterbur cannot be recommended for this or any other use in children at this time.