Generic: Bitter Melon
treats Diabetes mellitus, Human immunodeficiency virus, and Cancer
This information is based on a systematic review of scientific literature edited and peer- reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD (Memorial Sloan- Kettering Cancer center); Samuel Basch, MD (Mt. Sinai Medical Center); Lisa Cheung, PharmD (University of Rhode Island); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Cathi Dennehy, PharmD (University of California, San Francisco); Steven Gabardi, PharmD (Brigham and Women's Hospital/ Northeastern University); Nicole Giese, MS (Natural Standard Research Collaboration); Peter Glickman, MD (Harvard Medical School); Michael Goble, BS, PharmD (Massachusetts College of Pharmacy); Sadaf Hashmi, MD, MPH (Johns Hopkins School of Hygiene and Public Health); David Kroll, PhD (Duke University); Erica Rusie, PharmD (Natural Standard Research Collaboration); Michael Smith, MRPharmS, ND (Canadian College of Naturopathic Medicine); David Sollars, MAc, HMC (New England School of Acupuncture); Philippe Szapary, MD (University of Pennsylvania); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Northeastern University).
BibliographyDISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60(4):356- 359.
Bourinbaiar AS, Lee- Huang S. The activity of plant- derived antiretroviral proteins MAP30 and GAP31 against herpes simplex virus in vitro. Biochem Biophys Res Commun 1996;219(3):923- 929.
Bourinbaiar AS, Lee- Huang S. Potentiation of anti- HIV activity of anti- inflammatory drugs, dexamethasone and indomethacin, by MAP30, the antiviral agent from bitter melon. Biochem Biophys Res Commun 1995;208(2):779- 785.
Dans AM, Villarruz MV, Jimeno CA, et al. The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies. J Clin Epidemiol 2007;60(6):554- 559.
Das P, Sinhababu SP, Dam T. Screening of antihelminthic effects of Indian plant extracts: a preliminary report. J Altern Complement Med 2006;12(3):299- 301.
Day C, Cartwright T, Provost J, et al. Hypoglycaemic effect of Momordica charantia extracts. Planta Med 1990;56(5):426- 429.
Krawinkel MB, Keding GB. Bitter gourd (Momordica Charantia): A dietary approach to hyperglycemia. Nutr Rev 2006;64(7 Pt 1):331- 337.
Leatherdale BA, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia (karela). Br Med J (Clin Res Ed) 1981;282(6279):1823- 1824.
Lee- Huang S, Huang PL, Chen HC, et al. Anti- HIV and anti- tumor activities of recombinant MAP30 from bitter melon. Gene 1995;161(2):151- 156.
Lee- Huang S, Huang PL, Huang PL, et al. Inhibition of the integrase of human immunodeficiency virus (HIV) type 1 by anti- HIV plant proteins MAP30 and GAP31. Proc Natl Acad Sci USA 1995;92(19):8818- 8822.
Leung SO, Yeung HW, Leung KN. The immunosuppressive activities of two abortifacient proteins isolated from the seeds of bitter melon (Momordica charantia). Immunopharmacology 1987;13(3):159- 171.
Limtrakul P, Khantamat O, Pintha K. Inhibition of P- glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract. Cancer Chemother Pharmacol 2004 Dec;54(6):525- 30.
Raman A, Lau C. Anti- diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine 1996;2(4):349- 362.
Rebultan SP. Bitter melon therapy: an experimental treatment of HIV infection. AIDS Asia. 1995 Jul- Aug;2(4):6- 7.
Virdi J, Sivakami S, Shahani S, et al. Antihyperglycemic effects of three extracts from Momordica charantia. J Ethnopharmacol 2003;88(1):107- 111.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.