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  • Basic Info
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Generic: Berberine
treats Infectious diarrhea, Heart failure, Thrombocytopenia, Glaucoma, Parasitic infection, H. pylori infection, Hypercholesterolemia, Chloroquine-resistant malaria, Diabetes, and Trachoma
               



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Interactions

Interactions with Drugs

Berberine may counter or prevent irregular heartbeat. Caution is advised when taking berberine with other agents that alter heart rate.

Berberine may decrease the efficacy of tetracycline; in theory, berberine may decrease the efficacy of other agents with antibacterial activity.

Berberine bisulfate may stimulate platelet formation, and berberine may have an antiheparin action. Thus, berberine may interact with certain drugs that increase the risk of bleeding, and reduce their effectiveness. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti- platelet drugs such as clopidogrel (Plavix®), and non- steroidal anti- inflammatory drugs (NSAIDS) such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®). However, berberine may be hepatoprotective (liver protective) when administered before toxic doses of acetaminophen.

Berberine may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.

Berberine may decrease total and LDL cholesterol, as well as triglycerides. Caution is advised in patients taking any cholesterol- lowering agents.

There may be additive hypotensive (blood pressure lowering) effects and bradycardia (slowed heart rate) when combining berberine with agents that lower blood pressure. Caution is advised.

Berberine may modulate the expression and function of PGP- 170 in hepatoma cells. In theory, berberine may interact with antineoplastic agents.

Berberine and berberine sulfate have anti- inflammatory effects and may interact with COX- 2 inhibitors. COX- 2 inhibitor drugs include celecoxib (Celebrex®) and rofecoxib (Vioxx®).

Berberine may elevate the blood concentration of cyclosporin A. Caution is advised.

Berberine may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be increased in the blood, and may cause increased effects or potentially serious adverse reactions. Patients using any medications should check the package insert, and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.

Although not well studied in humans, there may be a potential for synergism between berberine chloride and fluconazole. Berberine and L- phenylephrine may have additive effects when administered concurrently. Furthermore, berberine may reverse the secretory properties of neostigmine (Prostigmin®).

Berberine and 1,3- bis (2- chloroethyl)- 1- nitosurea (BCNU) may have additive effects.

Berberine may increase sensitization to acetylcholine's hypotensive (blood pressure lowering) effects.

P- glycoprotein may contribute to the poor intestinal absorption of berberine.

It is been purported that berberine may have sedative effects. Although human study is lacking, caution is advised.

Berberine may competitively inhibit the binding of yohimbine to platelets. Patients taking yohimbine should consult with a qualified healthcare professional, including a pharmacist, to check for interactions.

Interactions with Herbs and Dietary Supplements

Berberine may counter or prevent irregular heartbeat. Caution is advised when taking berberine with other herbs that alter heart rate.

Berberine may decrease the efficacy of tetracycline; thus, in theory, berberine may decrease the efficacy of herbs with antibacterial activity.

Berberine bisulfate may stimulate platelet formation, and berberine may have an antiheparin action. Thus, berberine may interact with certain herbs that increase the risk of bleeding and reduce their effectiveness. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

There may be additive hypotensive (blood pressure lowering) effects and bradycardia (slowed heart rate) when combining berberine with herbs that lower blood pressure. Caution is advised.

Berberine may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.

Berberine may decrease total and LDL cholesterol, as well as triglycerides. Caution is advised in patients taking herbs or supplements with cholesterol- lowering effects, such as red yeast rice.

Concomitant use of berberine- containing herbs may increase the risk of berberine toxicity. Berberine- containing herbs include: bloodroot, goldenseal, celandine, Chinese goldthread, goldthread, Oregon grape (Mahonia species), amur cork tree, and Chinese corktree.

Berberine may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may become too high in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system.

Although not well studied in humans, berberine may have sedative effects.

Based on clinical study, tyramine- containing foods, such as wine, cheese, and chocolate, may have an interaction with berberine due to berberine's effect on decreasing levels of tyramine.

Berberine may competitively inhibit the binding of yohimbine to platelets. In addition, due to the antifertililty properties of berberine, use of yohimbe for fertility may not be effective.

Berberine may decrease the metabolism of vitamin B; therefore, the concomitant use of berberine with vitamin B should be avoided.

               
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