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  • Basic Info
Licensed from
Generic: Bacopa
treats Memory, Anxiety, Epilepsy, Irritable bowel syndrome, and Cognition

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Interactions with Drugs

Bacopa may additively interact with calcium blocking drugs. Caution is advised.

Bacopa may negatively affect cytochrome P450 enzymes and may interfere with the way the body processes certain drugs. As a result, the levels of these drugs may be altered in the blood. Patients taking any medications should check the package insert and consult with a qualified healthcare professional, including a pharmacist, about possible interactions.

Bacopa may increase thyroid hormones and could interact additively with hypothyroid medicine.

Bacopa, when taken concomitantly with phenytoin, may reverse phenytoin- induced cognitive impairment. Consult with a qualified healthcare professional, including a pharmacist, to check for interactions.

Interactions with Herbs and Dietary Supplements

Bacopa may negatively affect cytochrome P450 enzymes and interfere with the way the body processes certain herbs or supplements. As a result, the levels of other herbs or supplements may become too high in the blood. It may also alter the effects that other herbs or supplement possibly have on the P450 system.


This information is based on a systematic review of scientific literature edited and peer- reviewed by contributors to the Natural Standard Research Collaboration ( J. Kathryn Bryan, BA (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Verda Tunaligil, MD, MPH (Harvard School of Public Health); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

Chaudhuri PK, Srivastava R, Kumar S, et al. Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea. Phytother Res 2004;18(2):114- 117.

Chowdhuri DK, Parmar D, Kakkar P, et al. Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain. Phytother Res 2002;16(7):639- 645.

Goel RK, Sairam K, Babu MD, et al. In vitro evaluation of Bacopa monniera on anti- Helicobacter pylori activity and accumulation of prostaglandins. Phytomedicine 2003;10(6- 7):523- 527.

Kar A, Panda S, Bharti S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol 2002;81(2):281- 285.

Kishore K, Singh M. Effect of bacosides, alcoholic extract of Bacopa monniera Linn. (brahmi), on experimental amnesia in mice. Indian J Exp Biol 2005;43(7):640- 645.

Pawar R, Gopalakrishnan C, Bhutani KK. Dammarane triterpene saponin from Bacopa monniera as the superoxide inhibitor in polymorphonuclear cells. Planta Med 2001;67(8):752- 754.

Rao CV, Sairam K, Goel RK. Experimental evaluation of Bocopa monniera on rat gastric ulceration and secretion. Indian J Physiol Pharmacol 2000;44(4):435- 441.

Roodenrys S, Booth D, Bulzomi S, et al. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology 2002;27(2):279- 281.

Russo A, Borrelli F. Bacopa monniera, a reputed nootropic plant: an overview. Phytomedicine 2005;12(4):305- 317.

Russo A, Izzo AA, Borrelli F, et al. Free radical scavenging capacity and protective effect of Bacopa monniera L. on DNA damage. Phytother Res 2003;17(8):870- 875.

Samiulla DS, Prashanth D, Amit A. Mast cell stabilising activity of Bacopa monnieri. Fitoterapia 2001;72(3):284- 285.

Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl) 2001;156(4):481- 484.

Sumathy T, Govindasamy S, Balakrishna K, et al. Protective role of Bacopa monniera on morphine- induced brain mitochondrial enzyme activity in rats. Fitoterapia 2002;73(5):381- 385.

Sumathy T, Subramanian S, Govindasamy S, et al. Protective role of Bacopa monniera on morphine induced hepatotoxicity in rats. Phytother Res 2001;15(7):643- 645.

Vohora D, Pal SN, Pillai KK. Protection from phenytoin- induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant. J Ethnopharmacol 2000;71(3):383- 390.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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