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  • Basic Info
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Generic: Acacia
treats Plaque and Hypercholesterolemia

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Interactions with Drugs

Acacia may affect the absorption of amoxicillin when taken concurrently; doses should be separated by at least four hours.

Use of acacia as a surfactant (substance that lowers surface tension) may increase the intestinal absorption of some anticancer drugs.

Mixing acacia with a substance containing more than 50% concentration of ethyl alcohol may cause acacia to become insoluble.

Acacia can be gelatinized by solutions of iron salts.

Theoretically, the fiber in acacia may impair the absorption of oral drugs.

Interactions with Herbs and Dietary Supplements

Theoretically, the fiber in acacia may impair the absorption of oral herbs and supplements.

Theoretically, tannins from Acacia catechu L. plant may contribute to oral and esophageal cancer when combined with other substances that also contain high amounts of tannins.


Author/ Editors: Tracee Rae Abrams, PharmD (University of Rhode Island); Chi Dam, PharmD (Northeastern University); Mary Giles (University of Rhode Island); Adrianne Rogers, MD (Harvard Medical School); Erica Rusie, PharmD (Nova Southeastern University); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Lisa Wendt, PharmD (Albany College of Pharmacy).


DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Al Mosawi AJ. The challenge of chronic renal failure in the developing world: possible use of acacia gum. Pediatr Nephrol 2002;17(5):390- 391.

Al Mustafa ZH, Dafallah AA. A study on the toxicology of Acacia nilotica. Am J Chin Med 2000;28(1):123- 129. .

Boral D, Chatterjee S, Bhattacharya K. The occurrence and allergising potential of airborne pollen in West Bengal, India. Ann Agric Environ Med 2004;11(1):45- 52.

Clark DT, Gazi MI, Cox SW, et al. The effects of Acacia arabica gum on the in vitro growth and protease activities of periodontopathic bacteria. J Clin Periodontol 1993;20(4):238- 243.

Cvitanovic S, Znaor L, Perisic D, et al. Hypersensitivity to pollen allergens on the Adriatic coast. Arh Hig Rada Toksikol 2004;55(2- 3):147- 154.

Eltayeb IB, Awad AI, Elderbi MA, et al. Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob.Chemother 2004;54(2):577- 578.

Fotisch K, Fah J, Wuthrich B, et al. IgE antibodies specific for carbohydrates in a patient allergic to gum arabic (Acacia senegal). Allergy 1998;53(11):1043- 1051.

Gazi MI. The finding of antiplaque features in Acacia Arabica type of chewing gum. J Clin Periodontol 1991;18(1):75- 77.

Haridas V, Hanausek M, Nishimura G, et al. Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery. J Clin Invest 2004;113(1):65- 73.

Jensen CD, Haskell W, Whittam JH. Long- term effects of water- soluble dietary fiber in the management of hypercholesterolemia in healthy men and women. Am J Cardiol 1- 1- 1997;79(1):34- 37.

Jensen CD, Spiller GA, Gates JE, et al. The effect of acacia gum and a water- soluble dietary fiber mixture on blood lipids in humans. J Am Coll Nutr 1993;12(2):147- 154.

Li SS, Gao Z, Feng X, et al. Plant sterols as selective DNA polymerase beta lyase inhibitors and potentiators of bleomycin cytotoxicity. Bioorg Med Chem 8- 1- 2004;12(15):4253- 4258.

Pakrashi A, Ray H, Pal BC, et al. Sperm immobilizing effect of triterpene saponins from Acacia auriculiformis. Contraception 1991;43(5):475- 483.

Shah BH, Safdar B, Virani SS, et al. The antiplatelet aggregatory activity of Acacia nilotica is due to blockade of calcium influx through membrane calcium channels. Gen Pharmacol 1997;29(2):251- 255.

Vaishya R. A thorny problem: the diagnosis and treatment of acacia thorn injuries. Injury 1990;21(2):97- 100.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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