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  • Basic Info
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Generic: apap/caffeine/phenyltoloxamine/salicylamide
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It is used to relieve mild to moderate pain from headaches, the common cold, flu, or a sinus infection

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What is this medicine?

ACETAMINOPHEN; CAFFEINE; PHENYLTOLOXAMINE; SALICYLAMIDE (a set a MEE noe fen; KAF een; fen ill toe LOX a meen; sal i SILL a mide) is a pain reliever. It is used to relieve mild to moderate pain from headaches, the common cold, flu, or a sinus infection. It may also be used for pain from menstrual cramps, muscle or nerve pain, and arthritis.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • asthma
  • blood clotting problems
  • glaucoma
  • heart disease
  • high blood pressure
  • if you frequently drink alcohol containing drinks
  • kidney disease
  • liver disease
  • prostate problems
  • stomach ulcer or other problem
  • trouble passing urine
  • an unusual reaction to acetaminophen, caffeine, phenyltoloxamine, salicylamide, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast- feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years of age for selected conditions, precautions do apply.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methotrexate
  • probenecid

This medicine may also interact with the following medications:

  • acetaminophen
  • acetazolamide
  • alcohol
  • antibiotics like ciprofloxacin, gatifloxacin, tetracycline
  • aspirin and aspirin- like drugs
  • caffeine
  • green tea
  • lithium
  • medicines for allergies, congestion
  • medicines for asthma or other breathing problems
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for seizures like fosphenytoin, phenobarbital, phenytoin
  • medicines for sleep
  • muscle relaxants
  • varicella live vaccine
  • warfarin

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