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  • Basic Info
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Generic: APAP/chlorpheniramine/dextromethorphan/PE
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It is used to treat the aches and pains, cough, fever, congestion, runny nose, and sneezing of a cold
               



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What is this medicine?

ACETAMINOPHEN; CHLORPHENIRAMINE; DEXTROMETHORPHAN; PHENYLEPHRINE (a set a MEE noe fen; klor fen IR a meen; dex troe meth OR fan; fen il EF rin) is a combination of a pain reliever, an antihistamine, a cough suppressant, and a decongestant. It is used to treat the aches and pains, cough, fever, congestion, runny nose, and sneezing of a cold. This medicine will not treat an infection.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • asthma
  • cough that does not go away
  • cough with a lot of phlegm
  • diabetes
  • glaucoma
  • heart disease
  • high blood pressure
  • if you frequently drink alcohol containing drinks
  • liver disease
  • taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
  • thyroid disease
  • trouble passing urine
  • an unusual or allergic reaction to acetaminophen, chlorpheniramine, dextromethorphan, phenylephrine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast- feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the package label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • cocaine
  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • stimulant medicines like dextroamphetamine and others

This medicine may also interact with the following medications:

  • alcohol
  • bretylium
  • furazolidone
  • imatinib
  • isoniazid
  • linezolid
  • mecamylamine
  • medicines for anxiety or sleep
  • medicines for blood pressure like atenolol, clonidine, doxazosin, methyldopa, metoprolol
  • medicines for chest pain like isosorbide dinitrate, nitroglycerin
  • medicines for enlarged prostate like tamsulosin
  • medicines for sleep during surgery
  • other medicines for cold, cough or allergy
  • other medicines with acetaminophen
  • procarbazine
  • reserpine
  • St. John's Wort

               
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