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Wernicke's encephalopathy and Korsakoff syndrome are believed to be two stages of the same condition. Wernicke's encephalopathy is caused by damaging changes in the brain, usually due to a lack of vitamin B1 (thiamine).
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One of the main reasons that alcoholism leads to thiamine deficiency has to do with the high-calorie nature of alcohol. A person with a large alcohol intake often, in essence, substitutes alcohol for other, more nutritive calorie sources.
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Wernicke-Korsakoff syndrome is caused by thiamin deficiency. It is most commonly observed in.people with alcoholism since heavy drinkers often eat poorly, and alcoholism interferes with absorption of nutrients from the digestive system.
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vitamin B-1, thiamin (U.S. spelling), thiamine (European spelling) Thiamin is a member of the B family of vitamins (B Complex). It was the first water-soluble vitamin discovered. Like all the B vitamins, thiamin (or vitamin B-1) is best known for its role in the production of energy. Although rare in the United States, beriberi is the most common disease associated with thiamin deficiency.
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