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Hemoglobin is a protein inside red blood cells that carries oxygen. Sickle cell anemia is caused by an abnormal type of hemoglobin called hemoglobin S.
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Sickle cell anemia is caused by an error in the gene that signals the body how to make hemoglobin. The defective gene tells the body to make the abnormal hemoglobin HbS instead of the normal HbA, and this results in deformed red blood cells.
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Sickle cell anemia is suspected based on an individual's ethnic or racial background, and on the symptoms of anemia. A blood count reveals the presence of anemia, and a sickle cell test reveals the presence of the sickle cell trait.To confirm a di...
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Of the millions of people with sickle cell trait worldwide, a small handful of individuals have experienced acute symptoms. In these very rare cases, individuals were subject to very severe physical strain.When both members of a couple are carrier...
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The lower leg of this woman has ulcerated, necrotic tissue, resulting from sickle cell anemia.
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Humans normally make several types of the oxygen-carrying protein hemoglobin. An individual's stage in development determines whether he or she makes primarily embryonic, fetal, or adult hemoglobins.
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Of the millions of people with sickle cell trait worldwide, a small handful of individuals have experienced acute symptoms. In these very rare cases, individuals were subject to very severe physical strain.When both members of a couple are carrier...
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The term"hemoglobinopathy" has been used to describe abnormalities of hemoglobin, such as sickle-cell disease. Most common are those of hereditary origin in which there is a substitution of one or more of the amino acids in the amino acid chains t...
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Hemoglobinopathies are genetic(inherited) disorders of hemoglobin, the oxygen-carrying protein of the red blood cells.The hemoglobin molecule is composed of four separate polypeptide chains of amino acids, two alpha chains and two beta chains, as ...
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Autosomal recessive is one of several ways that a trait, disorder, or disease can be passed down through families.An autosomal recessive disorder means two copies of an abnormal gene must be present in order for the disease or trait to develop.Gen...
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Detailed information on autosomal recessive inheritance, including cystic fibrosis, sickle cell anemia, and Tay Sachs disease
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