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Preeclampsia Learning Center
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The term preeclampsia applies to a spectrum of disorders that are pregnancy-dependent, all accompanied(usually) by some degree of hypertension at some point in their evolution. Preeclampsia is subdivided into categories based on the severity of hy...
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I really could go on for many more posts related to hypertensive disorders in pregnancy, but I think I will call it quits(for awhile) after this one, lest I run the risk of boring to tears all of you who are not interested in the subject. If you h...
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In our last two posts, we have discussed the general significance of hypertensive disorders in pregnancy and the spectrum of pregnancy-induced hypertensive disorders classified as preeclampsia. The problem with preeclampsia is that most of the tim...
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In our last post on the subject of hypertensive disorders in pregnancy, we pointed out that once preeclampsia has developed, we are limited in our ability to treat the condition. Indeed, the only situations I have seen in which the clinical syndro...
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The old adage that the sun should not set on a severely preeclamptic woman until the placenta is in the bucket to be sent to pathology holds a lot of truth. Even then, the most severely affected women(and sometimes those not so severely affected b...
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Of course, there are times when the BP is so abnormal that we break this rule!. Chronic hypertension during pregnancy is usually defined as persistent hypertension from any cause that is present before 20 weeks gestation.
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Before I get into details regarding specific abnormalities of the maternal immune system and clotting system that appear to be related to recurrent early pregnancy loss, let me tell you a story about one of those special patients in my life who ch...
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There does appear to be a genetic predisposition/association with abnormalities in PAI-1 production and later pregnancy complications. Yamada and colleagues(J Hum Genet 2000;45:138-41) evaluated the association between preeclampsia and deletion/in...
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To ednanichols22: I think the first order of business is to find out for sure if you are really pregnant!. At your age, if you are pregnant, you are at VERY high risk for complications of your hypertension and also for having a baby with a chromos...
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Indeed, there is good evidence that abnormal early placental development plays a key role in setting the stage for a woman to eventually develop preeclampsia, especially in its most severe forms. We know that pregnancy is a prerequisite for preecl...
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We still do not know what causes preeclampsia, although in their various forms, hypertensive disorders of pregnancy account for 17.6% of all maternal deaths in the U.S. We still have no good screening test to define which women are at risk for pre...
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In our last post, we reviewed several studies that would lend support to the hypothesis that women with elevated levels of plasminogen activator inhibitor-1(PAI-1), and a genetic predisposition for the same, are at increased risk for adverse pregn...
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Recently, I was asked to see a very interesting patient in consultation. Although a favorable outcome of her pregnancy is by no means guaranteed at this time, I am fairly sure that the timely request from her physician for a curbside consult avert...
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Just as the fetal outcome depends on the degree, underlying cause, timing during development and longevity of decreased amniotic fluid, to some extent, so do the management options. When the baby has complete absence of both kidneys(bilateral rena...
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Prenatal maternal serum screening in midtrimester(AFP, estriol, hCG, and inhibin-A) is without doubt the most misunderstood test routinely offered to women during pregnancy. Misconceptions and uncertainty abound on the parts of both patients and p...
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