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Pneumococcal Meningitis Learning Center
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Meningitis is the most common serious manifestation of infection of the central nervous system (CNS). Inflammatory involvement of the subarachnoid space with meningeal irritation leads to the classic triad of headache, fever and meningism, and to a pleocytosis in the cerebrospinal fluid (CSF).
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Epidemiology and microbiology: the overall annual incidence of bacterial meningitis is about 2?3/100,000, with peaks of incidence in infants and adolescents. Integration of vaccines into the UK vaccination programme against Haemophilus influenzae type b (Hib) and more recently against group C meningococccus has led to a marked decline in cases of Hib and Group C meningococcal meningitis and has significantly reduced the overall incidence of bacterial meningitis.
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