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Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B-12 from the gastrointestinal tract. Vitamin B-12 is necessary for the formation of red blood cells. Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia. (See the general article - anemia ) Pernicious anemia is a type of megaloblastic anemia .
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Pernicious anemia is a disease in which the red blood cells are abnormally formed, due to an inability to absorb vitamin B 12 . True pernicious anemia refers specifically to a disorder of atrophied parietal cells leading to absent intrinsic factor, resulting in an inability to absorb B 12 .
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