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Paroxysmal Nocturnal Hemoglobinuria (PNH) Learning Center
Causes could include:
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mutation in a hematopoietic stem cell
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Persons with this disease have blood cells that are missing a gene called PIG-A. This gene allows a substance called glycosyl-phosphatidylinositol (GPI) to help certain proteins stick to cells.
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Mutations in any of 10 different genes can affect the production of GPI. Only one gene, however, is always altered in PNH. This is the PIG-A gene, located on the X chromosome. Females have two X chromosomes (only one is active) and males have one ...
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Mutations in any of 10 different genes can affect the production of GPI. Only one gene, however, is always altered in PNH. This is the PIG-A gene, located on the X chromosome . Females have two X chromosomes (only one is active) and males have one...
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