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Miscarriage Learning Center

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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:September 17, 2007
Dear Dr.- I am 6wk 4 days pregnant and just had an ultrasound, have seen the heartbeat- however, they have told me there is hemorraging- does this mean a miscarriage is inevitable?. Is it safer to let the miscarriage happen naturally or have a d&c?.
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:December 6, 2007
The"back ache" could also be uterine contractions associated with miscarriage or caused by something outside the uterus such as an ectopic pregnancy or ovarian cyst. At 7 weeks, your doctor can do a transvaginal ultrasound and should be able to co...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:August 12, 2007
Soumya has left a new comment on your post" Recurrent Early Pregnancy Loss- 6- A Special Pat...". (I have modified/revised her comment somewhat to the best of my understanding of her concerns)...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:August 17, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:December 22, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:April 5, 2007
Before I get into details regarding specific abnormalities of the maternal immune system and clotting system that appear to be related to recurrent early pregnancy loss, let me tell you a story about one of those special patients in my life who ch...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:April 3, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:March 25, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:March 24, 2007
In our last post we discussed the high frequency of early pregnancy losses in first conceptions that probably results from a naive maternal immune response to the fetal tissues; and also the high frequency of chromosomal abnormalities as the most ...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:March 22, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:March 16, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:March 15, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:February 7, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:December 18, 2007
In our last post, we reviewed several studies that would lend support to the hypothesis that women with elevated levels of plasminogen activator inhibitor-1(PAI-1), and a genetic predisposition for the same, are at increased risk for adverse pregn...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:November 5, 2007
Several recent comments on my post"MTHFR Mutations and Congenital Heart Defects" worthy of a general response for our readers: Anonymous said Sept 02, 09:30:00 PM 2007... My daughter was diagnosed with MTHFR gene mutation during a blood test befor...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:September 7, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:April 12, 2007
The readers who sent in the comments below related to recurrent early pregnancy loss(RPL) have what we could consider to be'borderline' indications for'treatment' and several questions related to their therapy. But, the fact remains, they have bot...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:December 9, 2007
The other day, tjtiger left a new comment on my post"MTHFR Mutations and Congenital Heart Defects". Her many questions made her comment worthy of a post of their own and the query related to the possible assocation of MTHFR polymorhisms and schizo...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:October 3, 2007
Anonymous has left a new comment on your post"Early Pregnancy Loss- 2": I found out from my OB today that I miscarried(I found out I was pregnant on 8/22, and began bleeding on 8/29, he ordered a hCG level test which went from 12 to 2 in a 48 hour...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:September 4, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:November 20, 2007
Back in June, a reader I.R. left a comment on my post"Recurrent Early Pregnancy Loss- 7- Immunologic a...". Her specific question related to the possible role of plasminogen activator inhibitor 1(PAI 1) activity and polymorphisms in recurrent preg...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:September 30, 2007
Below are excerpts from a comment/query that appeared recently on my post Recurrent Early Pregnancy Loss-6- A Special Patient. In this post, I recount my first experiences with a woman who had pregnancy complications(miscarriages and severe preecl...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:September 27, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:July 11, 2009
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:June 10, 2008
The last two major categories I would like to discuss related to recurrent early pregnancy loss are immunologic and hematological(thrombophilias) abnormalities. These may well be the most common causes, but they are also by far the least well unde...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:April 1, 2007
For many years now, we have placed women with recurrent early pregnancy loss on low-dose aspirin(81 mg) and heparin, or low molecular-weight heparin such as lovenox, to help them improve their prospects for pregnancy outcome. In some instances thi...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:January 26, 2008
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:February 9, 2009
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:September 1, 2008
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:July 19, 2008
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:December 15, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:April 28, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:September 6, 2009
My local hospital claims their amnio miscarriage rate is between 0.5 and 1.0 per cent. I am torn between no getting pregnant again given my age and driving myself ill with stress of not knowing for sure. many thanks anonymous.
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:January 22, 2008
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:September 11, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:February 14, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:August 31, 2009
I have a short cervix, but what has not appeared to be IC. With my first healthy pregnancy(2 prior miscarriages in the first trimester) my cervix shortened from 35mm to 22mm between 19 and 28 weeks.
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:January 14, 2008
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:September 15, 2008
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:July 5, 2009
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:June 8, 2009
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:March 8, 2008
Below is a sequence of comments between a reader and me related to the unending difficulties we encounter sorting out the cause of midtrimester pregnancy losses: Is it preterm labor, cervical incompetence, uterine infection, fetal chromosomal abno...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:March 1, 2008
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:September 25, 2009
I felt the comment below from a reader deserved a more thorough response than could be accommodated under the post upon which it was left and also might be of interest to other readers and providers who frequent this site. Anticoagulation during p...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:April 17, 2008
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:February 23, 2007
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Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:March 27, 2008
The following comment was recently received with the request to comment upon the possible association of"poor sperm quality" and recurrent pregnancy loss... Posted by Concerned_in_Canada to Fruit of the Womb at Thu Jan 31, 11:59:00 AM 2008"Early P...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:February 3, 2008
Today I received another comment to a post I wrote awhile back on aneuploidy(chromosomal abnormality) from a reader who has a first trimester baby that was found to have a cystic hygroma. With the growing acceptance of first trimester screening fo...
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:August 22, 2007
One of our readers left the comments/questions below that were worthy of a post for general consumption by interested readers... Anonymous has left a new comment on your post" Recurrent Early Pregnancy Loss- 3- Chromosomal C
Author:Kenneth F. Trofatter, Jr., MD, PhD
Date:August 29, 2007
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