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Metachromatic Leukodystrophy Learning Center
Causes could include:
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Deficiency of arylsulfatase
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MLD is usually caused by the lack of an important enzyme called arylsulfatase A. Because this enzyme is missing, chemicals called sulfatides build up in and damage the nervous system, kidneys, gallbladder, and other organs. In particular, the chem...
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MLD is caused by a deficiency of the enzyme arylsulfatase A (ARSA). Without properly functioning ARSA, a fatty substance known as sulfatide accumulates in the brain and other areas of the body such as the liver, gall bladder, kidneys, and/or splee...
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