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Medullary cystic kidney disease (MCKD) is very similar to the childhood disease familial juvenile nephronophthisis (NPH. Both lead to scarring of the kidney and formation of fluid-filled cavities (cysts) in the deeper parts of the kidney. In these...
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A single, abnormal gene on one of the autosomal chromosomes (one of the first 22 "non-sex" chromosomes) from either parent can cause certain diseases. One of the parents will usually have the disease (since it is dominant) in this mode of inheritance . Only one parent must have an abnormal gene in order for the child to inherit the disease.
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