Gaucher's Disease : Symptoms

Symptoms vary depending on the type of disease, but may include:Bone pain and fracturesCognitive impairmentEasy bruisingEnlarged spleen (splenomegaly)Enlarged liver (hepatomegaly)FatigueHeart valve problemsLung diseaseSeizuresSevere swelling (edem...

Gaucher disease is an inherited disease, caused by a defective GBA gene. The disease is recessive, meaning that a child has to inherit a defective gene from both the mother and the father in order to have the actual condition.Type 1 affects both c...

Many patients experience"bone crises," which are episodes of extreme pain in their bones.There is a wide array of other problems that occur with Gaucher disease, such as anemia(fewer than normal red blood cells). Just how these other symptoms are....

The gene is located on chromosome 1. As of 2000, there have been over 100 mutations described in this gene that causes Gaucher disease.

Many patients experience"bone crises," which are episodes of extreme pain in their bones.There is a wide array of other problems that occur with Gaucher disease, such as anemia(fewer than normal red blood cells). Just how these other symptoms are ...

A break of any size is called a fracture. If the broken bone punctures the skin, it is called an open fracture(compound fracture).A stress fracture is a hairline crack in the bone that develops because of repeated or prolonged forces against the b...

Detailed information on fractures, including types, causes, symptoms, diagnosis, and treatment

A child's bones heal the same way as an adult's. But since a child's bones are still growing, there are a few special concerns.

Detailed information on fractures, including types, causes, symptoms, diagnosis, and treatment

Detailed information on fractures, including types, causes, symptoms, diagnosis, and treatment

Detailed information on sports and fractures Fractures are breaks in the bone that are often caused by a blow or a fall. A fracture may be classified as a simple fracture (a thin fracture that may not run through the entire bone), or a compound fracture, in which the broken bone protrudes through the skin. Most fractures occur in the arms and legs. Symptoms may include tenderness over the bone, swelling of the affected area, deformity of the limb, and increased pain upon movement.

Detailed information on sports and fractures Fractures are breaks in the bone that are often caused by a blow or a fall. A fracture may be classified as a simple fracture (a thin fracture that may not run through the entire bone), or a compound fracture, in which the broken bone protrudes through the skin. Most fractures occur in the arms and legs. Symptoms may include tenderness over the bone, swelling of the affected area, deformity of the limb, and increased pain upon movement.

Detailed information on sports and fractures Fractures are breaks in the bone that are often caused by a blow or a fall. A fracture may be classified as a simple fracture (a thin fracture that may not run through the entire bone), or a compound fracture, in which the broken bone protrudes through the skin. Most fractures occur in the arms and legs. Symptoms may include tenderness over the bone, swelling of the affected area, deformity of the limb, and increased pain upon movement.

Bones are tough and resilient, but if you push them hard enough—if you fall on a hard surface, for instance—they can crack or break.

A fracture is a complete or incomplete break in a bone resulting from the application of excessive force. An injury may be classified as a fracture-dislocation when a fracture involves the bony structures of any joint with associated dislocation o...

A fracture is a complete or incomplete break in a bone resulting from the application of excessive force.A fracture usually results from traumatic injury to bones causing the continuity of bone tissues or bony cartilage to be disrupted or broken. ...

A fracture is a complete or incomplete break in a bone resulting from the application of excessive force.A fracture usually results from traumatic injury to a bone, causing the continuity of bone tissues or bony cartilage to be disrupted or broken...

A fracture is a crack or break in a bone. It results from the application of excessive force through injuries, such as a fall or a hard blow.Up to the age of 50, more men suffer from fractures than women because of occupational hazards.

Bone pain represents one of the most debilitating side effects of the metastases of high-incidence cancers such as breast, prostate, lung, and multiple myeloma(myelomatosis). Severe bone pain is frequent, reported by greater than 65% of patients s...

Splenomegaly is an enlargement of the spleen beyond its normal size.The spleen is an organ that is a part of the lymph system. It filters the blood and maintains healthy red and white blood cells and platelets.Because of its wide variety of functi...

Hepatomegaly is swelling of the liver beyond its normal size.If both the liver and spleen are enlarged, it is called hepatosplenomegaly.Hepatosplenomegaly; Enlarged liver; Liver enlargement.The lower edge of the liver normally comes just to the lo...

Expert-reviewed information summary about cognitive disorders and delirium as complications of cancer or its treatment. Supportive care and pharmacologic approaches to the management of cognitive disorders and delirium are discussed.

Most of us get bruises from bumping into something from time to time. Bruising sometimes increases with age, especially in women as the capillary walls become more fragile and the skin becomes thin.

Fatigue is a feeling of weariness, tiredness, or lack of energy.Fatigue is different from drowsiness. In general, drowsiness is feeling the need to sleep, while fatigue is a lack of energy and motivation.

Fatigue is physical and/or mental exhaustion that can be triggered by stress, medication, overwork, or mental and physical illness or disease.Everyone experiences fatigue occasionally. It is the body''s way of signaling its need for rest and sleep.

Boosting Your Energy provides information on the causes and treatments of persistent fatigue. Includes information on aging and energy, eating for energy, and boosting your energy.

Fatigue may be defined as a subjective state in which one feels tired or exhausted, and in which the capacity for normal work or activity is reduced. There is, however, no commonly accepted definition of fatigue when it is considered in the contex...

If the fatigue is related to a decrease in hemoglobin, or oxygen-carrying capacity of the blood, then replacing the red blood cells by transfusion or taking erythropoietin can help reduce fatigue. If the fatigue is not related to this, then it is important that the person with cancer learn ways to conserve energy. Energy is like money, and people only have a limited amount of it. Think carefully about how to spend it. What activities are most important? What activities help restore energy? These are the activities that people with cancer should spend their energy on. They need to ask for help to do the rest of the activities.

If you regularly feel weary after waking from a good night's sleep or for no apparent reason, it's time to find out why.

Fatigue is physical and/or mental exhaustion that can be triggered by stress, medication, overwork, or mental and physical illness or disease.Everyone experiences fatigue occasionally. It is the body''s way of signaling its need for rest and sleep.

Fatigue may be defined as a subjective state in which one feels tired or exhausted, and in which the capacity for normal work or activity is reduced. There is, however, no commonly accepted definition of fatigue when it is considered in the contex...

Fatigue is a feeling of exhaustion or loss of strength. The duration of fatigue for a patient with cancer has been found to last from one to two times the length of time between diagnosis and completion of treatment, so it is common for fatigue to...

If the person on chemotherapy has decreased hemoglobin, or oxygen-carrying capacity of the blood, and it seems like the low hemoglobin level will last for a while, then a medicine called PROCRIT® (Epoetin alfa) may be prescribed. This medicine is given as an injection to keep the hemoglobin at a higher level. This can sometimes manage fatigue. PROCRIT is for anemic chemotherapy patients with most types of cancer.

We currently understand some of the causes of fatigue but not all of them. Fatigue may be related to physical changes caused by cancer or its treatment (chemotherapy, biotherapy, radiotherapy, or surgery). It is reported that the fatigue people get when receiving cancer treatment is more severe than the fatigue healthy people get. In addition, this fatigue lasts longer and is not relieved by sleep. Studies have shown that low hemoglobin is also related to fatigue. Hemoglobin carries oxygen in the blood, so if it is low, the body cells do not get as much oxygen as they need. Also, people who are not well nourished, who don't drink enough fluid and are dehydrated, or who are not able to move around much tend to have fatigue more easily. Finally, the way a person handles stress, thinks, or behaves can influence fatigue.

Fatigue is a vague feeling of being tired, weak, or exhausted. It is often a symptom of cancer, when cancer is first diagnosed, or when cancer progresses (Ferrell et al, 1996). It is also the most common side effect of cancer treatment. Some people with cancer have described fatigue as being "tired to the bones” or "hitting a wall.” Others say it is the most distressing side effect of cancer treatment. Fatigue is different for everyone, so it is important that the person who is experiencing it describe how he or she feels. Fatigue may cause decreased ability to work or do physical activity. If the person with cancer is easily distracted and unable to concentrate on mental work or activity, then he or she may have attentional fatigue (Winningham and Barton-Burke, 2000). Depending upon its cause, fatigue can come and go or stay constant for a while. Fatigue from chemotherapy tends to occur a few days after the treatment, peaks, and then gets better before the next treatment. Fatigue from radiation doesn't happen right away. It develops over the first two to three weeks of treatment and then increases as the treatment continues. It may last three months or more after the treatment is finished. Attentional fatigue can last up until two or three years after treatment is completed.

Many people experience late-in-the-day energy lags, but you can take steps to prevent them.

Fatigue is a common side effect of chemotherapy and radiation therapy. It can be caused by worry, lack of sleep, and poor appetite. Fatigue can also be a sign of anemia (a shortage of red blood cells). This could require medical treatment. The tips below can help you feel better.

A seizure is the physical findings or changes in behavior that occur after an episode of abnormal electrical activity in the brain.Secondary seizures; Reactive seizures; Seizure- secondary; Seizure- reactive.There are a wide variety of possible sy...

A seizure is a sudden change in behavior characterized by changes in sensory perception(sense of feeling) or motor activity(movement) due to an abnormal firing of nerve cells in the brain. Epilepsy is a condition characterized by recurrent seizure...

Detailed information on epilepsy and seizures, including the different types of seizures, causes, symptoms, diagnosis, and treatment

A seizure is a sudden change in behavior characterized by changes in sensory perception(sense of feeling) or motor activity(movement) due to an abnormal firing of nerve cells in the brain. Epilepsy is a condition characterized by recurrent seizure...

Detailed information on epilepsy and seizures, including the different types of seizures, causes, symptoms, diagnosis, and treatment

Detailed information on epilepsy and seizures, including the different types of seizures, causes, symptoms, diagnosis, and treatment

The intense, involuntary muscular contractions that often accompany seizures are referred to as convulsions. Seizures normally last three to five minutes, with a period of unconsciousness that may last for up to 30 minutes.Seizures can result from...

Detailed information on epilepsy and seizures, including the different types of seizures, causes, symptoms, diagnosis, and treatment

Children with epilepsy may have seizures only once in a while, or every day. Though seizures can be scary for parents and caregivers, they aren't painful and are usually brief.

A seizure results from a sudden rush of abnormal electrical signals in the brain. Symptoms may range from a minor daze to uncontrollable muscle spasms (convulsion). In some cases, the victim may even lose consciousness. A seizure can be caused by a high fever, head injury, drug reaction, or condition such as epilepsy.

Although not a psychiatric disorder, epilepsy has a psychiatric aspect. The link is manifested in similar, often overlapping, symptoms, so it is important that caregivers diagnose and treat their patients with care.

People with certain mental conditions can experience seizures that appear to be epilepsy but are actually psychogenic seizures. Studies are finding ways to distinguish between the two types to facilitate proper treatment.

How does estrogen use and menopause affect someone with a seizure disorder?

Lung disease is any disease or disorder that occurs in the lungs or that causes the lungs to not work properly. There are three main types of lung disease:.Airway diseases-- These diseases affect the tubes(airways) that carry oxygen and other gase...

Detailed information on lung disorders and diseases, signs of respiratory distress, Chronic Obstructive Pulmonary Diseases (COPD), Asthma, Chronic Bronchitis, Pulmonary Emphysema, Acute Bronchitis, Cystic Fibrosis, Occupational Lung Diseases, Pneumonia, Primary Pulmonary Hypertension, Pulmonary Embolism, Pulmonary Sarcoidosis, Severe Acute Respiratory Syndrome (SARS), Tuberculosis

When you have COPD, you're more likely to develop a lung infection (pneumonia) with a cold or the flu. To stay healthier, avoid contact with germs. Get prompt treatment at the first sign of illness.

I have a spot on my lung that was picked up on a CAT scan of my abdomen. I am a non-smoker. What could this be besides cancer?

Chronic obstructive pulmonary disease encompases both emphysema and chronic bronchitis. This report covers treatment, medications, surgeries, and many practical techniques and exercises to improve your quality of life.

What causes lung nodules? Robert Shmerling, M.D., is associate physician and clinical chief of rheumatology at Beth Israel Deaconess Medical Center and an associate professor in medicine at Harvard Medical School. He is an active teacher in the Internal Medicine Residency Program, serving as the Robinson Firm Chief. He is also a teacher in the Rheumatology Fellowship Program and has been a practicing rheumatologist for over 25 years.

Valvular heart disease refers to several disorders and diseases of the heart valves, which are the tissue flaps that regulate the flow of blood through the four chambers of the heart.The human heart consists of four chambers—two upper chambe...

Detailed information on heart valve diseases, including causes, anatomy of the heart valves, disease symptoms, diagnostic, and treatment information

Valve disease occurs when a valve doesn't open or close the way it should. If a valve doesn't open all the way, the heart has to push blood through a smaller opening. If the valve doesn't close tightly, some blood will leak backward.

Aortic stenosis means your aortic valve has a problem opening. The left ventricle has to work harder to push the blood through the valve. In some cases, this extra work will make the muscle of the ventricle thicken. This type of stenosis can quickly get worse.

Aortic insufficiency means your aortic valve has problems closing. Blood leaks back through the valve. Extra blood may cause the ventricle to stretch. A stretched ventricle doesn't squeeze as well. In time, the heart won't move blood the way it should.

Mitral insufficiency means your mitral valve has problems closing, letting blood leak back through the valve. Mild cases of mitral insufficiency, when a small amount of blood leaks, rarely lead to problems. But severe cases can cause damage to the ventricle and heart muscle.

During heart valve surgery, one or more heart valves can be repaired or replaced. The decision whether to repair or replace a valve often can't be made until after surgery has begun. If a valve can't be repaired, it may be replaced with a prosthetic valve.

Mitral stenosis means the mitral valve stiffens and doesn't open right. Blood must move through a smaller opening. In severe cases, fluid can build up in the lungs, leading to coughing and breathing problems.

A problem with a heart valve will usually cause the heart to make a noise. Your doctor can hear this noise, called a murmur. But you can have a heart murmur and not have valve disease or any other heart problem. Other tests can help confirm the diagnosis of valve disease.

Mitral valve prolapse is the most common heart valve problem. With this problem, the valve bulges slightly back into the atrium when it closes. This may allow a tiny amount of blood to leak.

If you are having symptoms, certain medications can ease them. Other medications help prevent problems that may occur due to valve disease. Your doctor can discuss what medications might be right for you. Here are some types of medications that may be prescribed and what they do.