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Hypertension is an independent risk factor for coronary artery disease (CAD) and stroke, leading causes of morbidity and mortality in North America. Concern has been raised that there is inadequate outpatient detection, evaluation, and treatment of hypertension, and that this is resulting in increased hospital admissions with complications of untreated hypertension: heart failure, and end-stage renal disease [1] .
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After half a century of clinical experience and research, management of pulmonary arterial hypertension remains a challenge. Currently, data to support the use of standard therapies for pulmonary arterial hypertension (oxygen supplementation, diuretics, digoxin, anticoagulation, and calcium channel blockers) are mostly retrospective, uncontrolled prospective, or derived from other diseases with similar but not identical manifestations.
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