Tuesday, February 14, 2012
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Brittle Bone Disease (Osteogenesis Imperfecta) Learning Center

Symptoms could include:
All people with OI have weak bones, which makes them susceptible to fractures. Persons with OI are usually below average height (short stature). However, the severity of the disease varies greatly.
Source:ADAM
Date:August 7, 2009
Evidence suggests that OI results from abnormalities in the collagen gene COL1A1 or COL1A2 and possibly abnormalities in other genes. In OI, the genetic abnormality causes one of two things to occur. It may direct cells to make an altered collagen...
Source:Gale Encyclopedia of Children's Health
OI is usually inherited as an autosomal dominant condition. In autosomal dominant inheritance, a single abnormal gene on one of the autosomal chromosomes (one of the first 22 "non-sex" chromosomes) from either parent can cause the disease. One of ...
Source:Gale Encyclopedia of Medicine
If more pressure is put on a bone than it can stand, it will split or break. A break of any size is called a fracture. If the broken bone punctures the skin, it is called an open fracture (compound fracture. A stress fracture is a hairline crack i...
Source:ADAM
Date:May 2, 2009
A fracture is a crack or break in a bone. It results from the application of excessive force through injuries, such as a fall or a hard blow.
Source:Gale Encyclopedia of Alternative Medicine
A fracture is a complete or incomplete break in a bone resulting from the application of excessive force.
Source:Gale Encyclopedia of Medicine
A fracture is a complete or incomplete break in a bone resulting from the application of excessive force. An injury may be classified as a fracture-dislocation when a fracture involves the bony structures of any joint with associated dislocation o...
Source:Gale Encyclopedia of Nursing and Allied Health
A fracture is a complete or incomplete break in a bone resulting from the application of excessive force.
Source:Gale Encyclopedia of Children's Health
Short stature refers to any person who is significantly below the average height for a person of the same age and sex. The term often refers to children or adolescents who are significantly below the average height of their peers.
Source:ADAM
Date:September 13, 2009
Hearing loss is the total or partial inability to hear sound in one or both ears. See also: Hearing loss of aging
Source:ADAM
Date:April 13, 2009
Hearing impairment is the temporary or permanent loss of some or all hearing in one or both ears.
Source:Gale Encyclopedia of Children's Health
Hearing loss is any degree of impairment of the ability to apprehend sound.
Source:Gale Encyclopedia of Medicine
Hearing loss is any degree of impairment of the ability to comprehend sound.
Source:Gale Encyclopedia of Nursing and Allied Health
Hearing begins in the womb—pregnant women have reported feeling the fetus move in response to loud noises at 31 weeks (7 weeks before full-term delivery). Newborns are sensitive to the location, frequency, pitch, and volume of sounds. Loud sounds ...
Source:Gale Encyclopedia of Childhood and Adolescence
Hearing loss is any degree of impairment of the ability to apprehend sound.
Source:Gale Encyclopedia of Alternative Medicine
Osteomalacia is softening of the bones due to a lack of vitamin D or a problem with the body's ability to break down and use this vitamin.
Source:ADAM
Date:July 15, 2008
Osteomalacia is a disease in which insufficient mineralization leads to a softening of the bones. Usually, this is caused by a deficiency of vitamin D , which reduces bone formation by altering calcium and phosphorus metabolism . Osteomalacia can ...
Source:Gale Nutrition and Well-Being A to Z
The spine is a shaft comprised of over 25 small bones called vertebrae that support the upper body. The cervical spine (C-spine) is the upper portion, comprised of 7 vertebrae.
Source:Healthline
Date:December 31, 2007
Hearing loss can be caused by many things – some reversible such as wax buildup in the ear canal or ear infections with fluid build up. Some hearing loss is irreversible – that due to mechanical problems within the ear itself, or sensorineural problems within the inner ear.
Source:Healthline
Date:November 30, 2007
Hypermobile joints are joints that move beyond the normal range with little effort. Joints most commonly affected are the elbows, wrists, fingers, and knees.
Source:ADAM
Date:November 30, 2008
A bruise is an area of skin discoloration. A bruise occurs when small blood vessels break and leak their contents into the soft tissue beneath the skin.
Source:ADAM
Date:May 2, 2009
Bruises, or ecchymoses, are a discoloration and tenderness of the skin or mucous membranes due to the leakage of blood from an injured blood vessel into the tissues. Pupura refers to bruising as the result of a disease condition. A very small brui...
Source:Gale Encyclopedia of Alternative Medicine
Bruises, or ecchymoses, are a discoloration and tenderness of the skin or mucous membranes due to the leakage of blood from an injured blood vessel into the tissues. Pupura refers to bruising as the result of a disease condition. A very small brui...
Source:Gale Encyclopedia of Medicine
Bruises, or ecchymoses, are a discoloration and tenderness of the skin or mucous membranes due to the leakage of blood from an injured blood vessel into the tissues. Purpura refers to bruising as the result of a disease condition. A very small bru...
Source:Gale Encyclopedia of Children's Health
True muscle weakness means that full effort does not produce a normal muscle contraction or movement. A voluntary muscle contraction is generated when the brain sends a signal through the spinal cord and nerves to a muscle.
Source:Healthline
Date:September 30, 2007
Weakness is a reduction in the strength of one or more muscles.
Source:ADAM
Date:August 8, 2009
Skeletal limb abnormalities refer to a variety of bone structure problems in the arms or legs (limbs.
Source:ADAM
Date:March 14, 2009
Pes planus is a condition in which the arch or instep of the foot collapses and comes in contact with the ground. In some individuals, this arch never develops while they are growing.
Source:ADAM
Date:March 4, 2009
Most of us get bruises from bumping into something from time to time. Bruising sometimes increases with age, especially in women as the capillary walls become more fragile and the skin becomes thin.
Source:Healthline
Date:November 30, 2007
A low nasal bridge is a flattening of the top part of the nose.
Source:ADAM
Date:February 27, 2008
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