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Adrenoleukodystrophy is passed down from parents to their children as an X-linked genetic trait. It therefore affects mostly males, although some women who are carriers can have milder forms of the disease.
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ALD is caused by a mutation in a gene called the ALD gene. Genes contain the instructions for how the body grows and develops before and after a person is born.
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ALD is caused by a mutation in a gene called the ALD gene. Genes contain the instructions for how the body grows and develops before and after a person is born.
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ALD causes problems in the peroxisomes, tiny cellular structures that are involved in breaking down large molecules of fats into smaller ones that can be used by the body. In ALD, the peroxisomes cannot break down a type of fat called very long ch...
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The genetic defect in ALD causes a decrease in the ability to degrade very long chain fatty acids. These build up in the adrenal glands, brain, plasma, and fibroblasts.
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In a strict sense, mutations are changes in genes not caused by genetic recombination. A change in the base sequence of DNA, for example, represents a mutational change.
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