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The Nicotine Reduction Strategy

Jonathan Foulds, MA, MAppSci, PhD
In my last post I mentioned a “regulated nicotine reduction strategy” that has been proposed numerous times over the past 10 years or so, but most consistently by Professor Neal Benowitz of the University of California at San Francisco. I mentioned some potential pros and cons to the strategy, and also mentioned an alternative strategy that could be called a “regulated toxin reduction strategy”, whereby cigarette manufacturers are required to reduce the permissible toxin deliveries from cigarettes (i.e. carbon-monoxide, NNK, lead etc) while potentially leaving the nicotine delivery stable. The logical end-point of this strategy is a product that does not require burning of tobacco or inhalation of smoke, but is capable of delivering sufficient nicotine to feed the smoker’s addiction.

It is fairly easy to present these two strategies as competing with each other, as they may be considered as mirror images of each other. One aims to take the addictive agent out of cigarettes, and the other aims to take out the toxins while leaving nicotine intact. Some may accuse these strategies of being “prohibition” in disguise. In determining whether either really involves prohibition it’s worth comparing them to the prohibition of alcohol that was attempted in the United States 1920s. That law prohibited the manufacture, sale and transportation of alcohol (not its consumption). Note it was the drug – alcohol – that was banned, not beer or whiskey per se. So the analogous prohibition relating to tobacco would involve a ban on the manufacture, sale or transportation of products containing nicotine. In fact no one has proposed such a law (that I’m aware of). The Benowitz proposal involves reductions to extremely low levels of the nicotine allowed in cigarettes, but may allow nicotine to be available in other forms (e.g. pharmaceutical nicotine gum). This is therefore not prohibition of nicotine.

The other point I want to make is that the 2 strategies could end up in a very similar situation if they focus on reducing permissible nicotine levels in smoked products but allow nicotine to remain in smokeless products (whether they be nicotine gum or snuff). With each strategy a point will come when cigarettes and other forms of smoked tobacco can no longer sustain their place in the market, and people who want to continue to take nicotine will have to do so in a smokeless form (and therefore avoid the very high risks of lung cancer and emphysema caused by inhaling smoke into the lungs).

At this moment this is something of an academic debate, because tobacco remains relatively unregulated in the US, and even if an agency like FDA were given the power to regulate tobacco one cannot be sure how or even if they would exercise that power. For the foreseeable future, smokers should focus their attention on trying to quit smoking completely. Hopefully some of the tips in my previous posts will help increase the chances of success.

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2 Comments:

  • At Thu Jun 21, 11:57:00 PM 2007, Anonymous Anonymous said…

    I find Dr Foulds comments rather weak in terms of scientific facts and poorly informed in terms of regulation. Reduce a toxin notion is only useful if the toxin bears a relationship to the problem and whether or not it's removal is practicable. The removal of NNK may be quite practitable and may make sense but what human data and mechanistic studies in a variety of species including humans support this? What will the impact on the smoker be, ie risk assessment? I think that cadmium which has lots of human data is a more scientifically based toxin than NNK As to regulation , if he means he wants more regulation , I agree. It is already regulated by the FTC , BATF and is required by law to submit lists of ingredients used to HHS. Can FDA regulation be important , yes....As to lowering nicotine..that sounds like a good mind experiment. Where is the data to support the expected outcome?

     
  • At Sat Jun 23, 04:53:00 PM 2007, Blogger Jonathan Foulds, MA, MAppSci, PhD said…

    Thanks for being blunt in your comment, but I think you misunderstood my main points:
    1. With cigarette smoke containing over 4000 chemicals trying to regulate any single on will be useless unless that one is a key marker of how the product is used overall.
    2. With nicotine you are taking out the main substance causing people to use the product. With Carbon-monoxide you are taking out a basic marker of the product being burned and inhaled.

    Taking all the cadmium out of cigarette smoke would be fine but would likely have only a trivial effect on the health effects of tobacco smoking.

    Like the commentator, I AM arguing for more regulation. I support the current FDA bill, but I suspect that we could reduce harm faster by eliminating smoke than nicotine.

     

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