sodium bicarbonate : Complexes, Storage & Clinical Research on Healthline.com

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Dissociates to provide bicarbonate ion; bicarbonate is the conjugate base component of the principal extracellular buffer in the body, the bicarbonate:carbonic acid buffer. Changes in the concentration of either component of the buffer can cause a decrease or increase in pH.

Administration of sodium bicarbonate, by decreasing pH, can cause a redistribution of potassium ions into cells in patients with acidosis.

Provides bicarbonate, which is readily excreted in urine; administration of the drug will increase urinary pH in patients with normal renal function. Alkalinizing the urine can increase the solubility of certain weak acids (e.g., cystine, uric acid) and can increase the ionization and urinary excretion of lipid-soluble organic acids (e.g., phenobarbital, salicylates) that are reabsorbed in the kidney via diffusion of the un-ionized species.

Potent antacid action; each gram of sodium bicarbonate has an in vitro neutralizing capacity of about 12 mEq of acid.

Advice to Patients

Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs as well as any concomitant illnesses.

Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.

Importance of informing patients of other important precautionary information. (See Cautions.)

Preparations

**Sodium Bicarbonate**
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Oral	Powder*		Arm & Hammer^® Baking Soda	Church & Dwight
	Tablets	325 mg*	Soda Mint (with peppermint oil)	CMC
			Sodium Bicarbonate Tablets	CMC, Rugby
		650 mg*
Parenteral	Injection	4.2% (0.5 mEq/mL) (2.5 or 5 mEq)*	Sodium Bicarbonate Injection	American Pharmaceutical Partners, Hospira
		5% (0.595 mEq/mL) (297.5 mEq)*	Sodium Bicarbonate Injection	Baxter, Hospira
		7.5% (0.892 mEq/mL) (8.92 or 44.6 mEq)*	Sodium Bicarbonate Injection	American Pharmaceutical Partners, American Regent, Hospira
		8.4% (1 mEq/mL) (10 or 50 mEq)*	Sodium Bicarbonate Injection	American Pharmaceutical Partners, American Regent, Hospira
	Injection, for preparation of IV admixtures	7.5% (0.892 mEq/mL) (178.4 mEq) pharmacy bulk package	Sodium Bicarbonate Injection MaxiVial^®	American Pharmaceutical Partners
	Solution, sterile, to adjust pH of injections	4% (0.48 mEq/mL) (2.4 mEq)	Neut^® (with edetate disodium)	Hospira
		4.2% (0.5 mEq/mL) (2.5 mEq)	Sodium Bicarbonate Additive Solution	American Pharmaceutical Partners
* available generically

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Colyte with Flavor Packs 240GM Solution for Reconstitution	ALAVEN PHARMACEUTICALS, LLC	4000/$30 or 8000/$55.2
SM Effervescent Pain Relief 325-1000-1916MG Effervescent Tablets	MCKESSON VALU-RITE	36/$8.99 or 108/$9.39
Sodium Bicarbonate 650MG Tablets	URL	1000/$20 or 2000/$29
Zegerid 40-1100MG Capsules	SANTARUS	30/$150.84 or 90/$419.52

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Drug Notebook

Generic Name: sodium bicarbonate

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Advice to Patients

Preparations

Comparative Pricing