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Generic Name: nortriptyline

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A tricyclic - treats Depression

FDA Alerts

Suicidality

Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. Nortriptyline is not approved for use in pediatric patients. (See Pediatric Use under Cautions.)
In pooled data analyses, risk of suicidality was not increased in adults >24 years of age and apparently was reduced in adults ≥65 years of age with antidepressant therapy compared with placebo.
Depression and certain other psychiatric disorders are themselves associated with an increased risk of suicide.
Appropriately monitor and closely observe all patients who are started on nortriptyline therapy for clinical worsening, suicidality, or unusual changes in behavior; involve family members and/or caregivers in this process. (See Worsening of Depression and Suicidality Risk under Cautions.)

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Nortriptyline Hydrochloride
MYLAN 3250 / MYLAN 3250 50 mg	NORTRIPTYLINE / DAN 25 mg 25 mg	GG 567 / GG 567 50 mg	NORTRIPTYLINE 75 mg / 253 CP 75 mg
93 812 50 mg 50 mg	93 811 25 mg 25 mg	MYLAN 1410 / MYLAN 1410 10 mg	NORTRIPTYLINE / DAN 75 mg 75 mg
93 813 75 mg 75 mg	MYLAN 4175 / MYLAN 4175 75 mg	GG 566 / GG 566 25 mg	NORTRIPTYLINE / DAN 50 mg 50 mg
MYLAN 2325 / MYLAN 2325 25 mg	NORTIPTYLINE / DAN 10 mg 10 mg
Pamelor
PAMELOR 25 mg / SANDOZ 25 mg	PAMELOR10MG / SANDOZ 10 mg

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nortriptyline

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(nor TRIP ti leen)

Advice to Patients

Risk of suicidality; importance of patients, family, and caregivers being alert to and immediately reporting emergence of suicidality, worsening depression, or unusual changes in behavior, especially during the first few months of therapy or during periods of dosage adjustment. FDA recommends providing written patient information (medication guide) explaining risks of suicidality each time the drug is dispensed.
Importance of considering possible impaired ability to perform hazardous activities (e.g., operating machinery, driving a motor vehicle).
Importance of patients understanding that it may take more than 2 weeks before the full effects are apparent.
Importance of avoiding alcohol-containing beverages or products.
Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed.
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses or planned surgery.
Importance of informing patients of other important precautionary information. (See Cautions.)

Preparations

**Nortriptyline Hydrochloride**
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Oral	Capsules	10 mg (of nortriptyline)*	Nortriptyline Hydrochloride Capsules	Mylan, Teva, Watson
			Pamelor^® (with benzyl alcohol and parabens)	Mallinckrodt
		25 mg (of nortriptyline)*	Nortriptyline Hydrochloride Capsules	Mylan, Teva, Watson
			Pamelor^® (with benzyl alcohol and parabens)	Mallinckrodt
		50 mg (of nortriptyline)*	Nortriptyline Hydrochloride Capsules	Mylan, Teva, Watson
			Pamelor^® (with benzyl alcohol parabens and sodium bisulfite)	Mallinckrodt
		75 mg (of nortriptyline)*	Nortriptyline Hydrochloride Capsules	Mylan, Teva
			Pamelor^® (with benzyl alcohol and parabens)	Mallinckrodt
	Solution	10 mg (of nortriptyline) per 5 mL*	Nortriptyline Hydrochloride Oral Solution	Pharmaceutical Associates, Ranbaxy
			Pamelor^® (with alcohol 4%)	Mallinckrodt
* available generically

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Nortriptyline HCl 10MG/5ML Solution	PHARMACEUTICAL ASSOCIATES	473/$52.98 or 1419/$149.99
Nortriptyline HCl 25MG Capsules	TEVA PHARMACEUTICALS USA	30/$12.99 or 60/$15.98
Nortriptyline HCl 50MG Capsules	TEVA PHARMACEUTICALS USA	30/$12.99 or 60/$17.98
Nortriptyline HCl 75MG Capsules	TEVA PHARMACEUTICALS USA	30/$12.99 or 60/$18.98
Pamelor 10MG Capsules	MALLINCKRODT	30/$523.14 or 90/$1443.83
Pamelor 10MG/5ML Solution	MALLINCKRODT	300/$159.99 or 900/$461.88
Pamelor 25MG Capsules	MALLINCKRODT	30/$499.54 or 90/$1424.04
Pamelor 50MG Capsules	MALLINCKRODT	30/$455.96 or 90/$1359.9
Pamelor 75MG Capsules	MALLINCKRODT	30/$540.38 or 90/$1450.5

AHFS Drug Information. © Copyright, 1959-2008, Selected Revisions September 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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