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Generic Name: ipratropium

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An anticholinergic bronchodilator - used forChronic Obstructive Pulmonary Disease

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ipratropium

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(IP ra TRO pee um)

Uses

Bronchospasm in COPD

Long-term treatment of reversible bronchospasm associated with COPD, including chronic bronchitis and emphysema.

Fixed combination with albuterol sulfate is used for the symptomatic management of bronchospasm associated with COPD in patients who continue to have evidence of bronchospasm despite the regular use of an orally inhaled bronchodilator and who require a second bronchodilator.

Bronchospasm in Asthma

Has been used for symptomatic treatment of acute or chronic bronchial asthma†; β₂-adrenergic agonist bronchodilators generally preferred initially for relief of bronchospasm in asthmatic patients.

May be useful as alternative therapy in adults experiencing adverse effects (e.g., tachycardia, arrhythmia, tremor) with a β-adrenergic agonist†.

Some clinicians consider ipratropium as adjunctive therapy in patients with moderate or severe exacerbations (peak expiratory flow rate ≤80% of predicted) of asthma† who fail to respond adequately to β-adrenergic agonists and corticosteroids.

May be useful for prevention or reversal of bronchospasm induced by β-adrenergic blocking agents† (e.g., propranolol) in asthmatic patients; β-adrenergic bronchodilators generally ineffective for this indication in such patients.

Dosage and Administration

Administration

Administer by oral inhalation using an oral aerosol inhaler or via nebulization.

Oral Inhalation via Metered-dose Aerosol

Ipratropium Bromide

Aerosol delivers ≥200 metered sprays per canister.

Patient should be instructed to clear excessive sputum from chest before inhalation.

Shake well immediately prior to use. Actuate aerosol inhaler 3 times prior to the initial use or if it has not been used for >24 hours.

Do not use mouthpiece for other aerosol drugs.

Exhale slowly and completely and place the mouthpiece of the inhaler well into the mouth with the lips closed around it. To avoid contact of the drug with the eyes and subsequent adverse effects, close eyes during inhalation of aerosol. Inhale slowly and deeply through the mouth while actuating the inhaler. Hold the breath for 10 seconds, withdraw the mouthpiece, and exhale slowly.

Allow ≥15 seconds to elapse between subsequent inhalations from the aerosol inhaler.

Wash the mouthpiece in hot running water as needed. If soap is used, rinse mouthpiece thoroughly with plain water.

Ipratropium Bromide and Albuterol Sulfate

Aerosol delivers ≥200 metered sprays per canister.

Shake well immediately prior to use. Actuate 3 times prior to the initial use or if it has not been used for >24 hours. Do not use actuator provided for other aerosol drugs. To avoid contact of the drug with the eyes and subsequent adverse effects, close eyes during inhalation of aerosol.

Exhale deeply and place mouthpiece of the inhaler into the mouth. Inhale slowly and deeply through the mouth while actuating the inhaler. Hold the breath for 10 seconds, withdraw the mouthpiece, and exhale slowly. Allow approximately 2 minutes to elapse and repeat the procedure. Rinse the mouthpiece in hot water as needed. If soap is used, rinse the mouthpiece thoroughly with plain water. When dry, replace the cap on the mouthpiece when the inhaler is not in use.

Oral Inhalation via Nebulization

Ipratropium Bromide

Empty entire contents of the single-use vial of solution into the nebulizer reservoir and attach reservoir to the mouthpiece or face mask and to the compressor according to the manufacturer’s instructions.

Use care when a face mask is used to avoid leakage since transient blurred vision and other adverse effects may result if the drug enters the eyes. (See Ocular Effects under Cautions.) Use of a mouthpiece may avoid inadvertent entry of drug into the eye.

Place the mouthpiece of the nebulizer in the mouth or put on the nebulizer face mask. Breathe as calmly, deeply, and evenly as possible until the nebulizer stops producing mist.

Duration of treatment usually is about 5–15 minutes.

Ipratropium Bromide and Albuterol Sulfate

Place the mouthpiece of the nebulizer in the mouth or put on the nebulizer face mask. Breathe as calmly, deeply, and evenly as possible until the nebulizer stops producing mist.

Duration of treatment usually is about 5–15 minutes.

Clean the nebulizer after use according to the manufacturer’s instructions.

Dosage

Available as ipratropium bromide.

Dosage of oral inhalation aerosol expressed in terms of the monohydrate.

Dosage of inhalation solution for nebulization expressed in terms of anhydrous drug.

Using in vitro testing at an average flow rate of 3.6 L per minute for an average of ≤15 minutes, the Pari-LC Plus^® nebulizer delivered at the mouthpiece approximately 46 or 42% of the original dosage of albuterol or ipratropium bromide, respectively.

Pediatric Patients

COPD

Inhalation

Patients ≥12 years of age: 36 mcg (2 inhalations) 4 times daily via a metered-dose aerosol, given alone or in fixed combination with albuterol (90 mcg via the mouthpiece). Additional inhalations should not exceed 216 mcg (12 inhalations) of ipratropium bromide in 24 hours.

Patients ≥12 years of age: 500 mcg (contents of 1 unit-dose vial) 3 or 4 times daily (i.e., every 6–8 hours) via a nebulizer.

Adults

COPD

Inhalation

Initially, 36 mcg (2 inhalations) 4 times daily via a metered-dose aerosol, given alone or in fixed combination with albuterol (90 mcg from the mouthpiece). Additional inhalations should not exceed 216 mcg (12 inhalations) in 24 hours.

Initially, 500 mcg 3 or 4 times daily (i.e., every 6–8 hours) via a nebulizer. With ipratropium bromide in fixed combination with albuterol sulfate (DuoNeb^®), 500 mcg 4 times daily. Additional inhalations should not exceed 6 inhalations daily.