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Drug Notebook

Generic Name: hyoscyamine

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IB-Stat, Symax FasTab, HyoMax SR, HyoMax SL, Levsin SL, Anaspaz, Symax SR, Hyoscyamine Sulfate SR, HyoMax FT, Hyosyne, Levbid, Levsin, Nulev, Donnamar, Hyosol, Hyospaz, Spasdel, Cystospaz-M, Symax SL, Levsinex SR, Cystospaz, Hyoscyamine TR, Hyoscyamine Hydrobromide, Symax Duotab, A-Spas S/L
An anticholinergic/antispasmodic - used forEndoscopy or Radiology Premedication and treats Irritable... more
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hyoscyamine
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(hye oh SYE a meen)

Drug Interactions

Drugs with Anticholinergic Effects

Possible additive adverse effects resulting from cholinergic blockade (e.g., xerostomia, blurred vision, constipation). Inform patient of this possibility.

Effects on GI Absorption of Drugs

By inhibiting the motility of the GI tract and prolonging GI transit time, antimuscarinics have the potential to alter GI absorption of various drugs.

Specific Drugs

Drug Interaction Comments
Acetaminophen Possible delay in onset of therapeutic effects (e.g., analgesia, antipyresis) of acetaminophen
Amantadine Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Antacids Decreased GI absorption of hyoscyamine Administer oral hyoscyamine at least 1 hour before antacids; some manufacturers recommend administering hyoscyamine before meals and antacids after meals to prolong effects of postprandial antacid therapy, but no substantial difference in gastric pH demonstrated with such combined therapy
Antiarrhythmic (anticholinergic) agents Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Anticholinergic drugs Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Antidepressants, tricyclic Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Antihistamines (anticholinergic) (including meclizine) Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Antiparkinsonian (antimuscarinic) agents Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Corticosteroids Possible increased IOP
Digoxin (slow dissolving) Possible increased serum digoxin concentration

Use digoxin oral solution (elixir) or rapidly dissolving tablets (e.g., Lanoxin®)

Observe closely for signs of digitalis toxicity

Glutethimide Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Haloperidol Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Ketoconazole Increased gastric pH decreases ketoconazole absorption Administer hyoscyamine at least 2 hours after ketoconazole
Levodopa Possible increased GI metabolism of levodopa and decreased systemic concentrations Adjust levodopa dosage if hyoscyamine is started or discontinued
MAO inhibitors Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Meperidine Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Muscle (anticholinergic) relaxants Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Phenothiazines Possible additive adverse effects resulting from cholinergic blockade Inform patient of this possibility
Potassium chloride Slowed GI transit potentiates adverse GI effects of oral potassium chloride (especially wax-matrix tablets) Caution if used concomitantly; monitor for possible GI mucosal lesions
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Uses Dosage and Administration Cautions Drug Interactions Pharmacokinetics Stability Actions Advice to Patients Preparations
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