Actions
- Inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also in the ascending limb of the loop of Henle. Does not inhibit carbonic anhydrase and is not an aldosterone antagonist.
- Mechanism of hypotensive effect not definitively determined but presumed to result from decreased plasma volume.
- Induces greater diuresis and electrolyte loss than with thiazides or most other diuretics except ethacrynic acid.
- Possesses some renal vasodilator effect; renal vascular resistance decreases and renal blood flow increases following administration.
Advice to Patients
- Risks associated with excessive fluid loss or electrolyte imbalance.
- Potential for postural hypotension; importance of rising slowly from a seated position.
- Importance of discussing dietary measures and supplementation to prevent or correct hypokalemia.
- Importance of informing patients with diabetes mellitus that blood glucose and urine glucose concentrations may increase.
- Importance of informing patients of possible photosensitivity.
- Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs (e.g., appetite suppressants, cold remedies) as well as any concomitant illnesses.
- Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.
- Importance of informing patients of other important precautionary information. (See Cautions.)
Preparations
Furosemide
| Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|
| Oral | Solution | 40 mg/5 mL* |
Furosemide Solution (with alcohol 0.2% and sorbitol) | Roxane |
| | 10 mg/mL* |
Furosemide Solution | Morton Grove, Roxane |
| Tablets | 20 mg* |
Furosemide Tablets | IVAX, Mylan, Qualitest, Roxane, Sandoz, UDL |
| | |
Lasix® | Sanofi-Aventis |
| | 40 mg* |
Furosemide Tablets | IVAX, Mylan, Qualitest, Roxane, Sandoz, UDL |
| | |
Lasix® (scored) | Sanofi-Aventis |
| | 80 mg* |
Furosemide Tablets | Mylan, Qualitest, Roxane, Sandoz, UDL |
| | |
Lasix® | Sanofi-Aventis |
| Parenteral | Injection | 10 mg/mL* |
Furosemide Injection | American Pharmaceutical Partners, American Regent, Hospira, IMS |
| * available generically |
Comparative Pricing
This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
| Furosemide 10MG/ML Solution | MORTON GROVE PHARMACEUTICALS | 120/$15.98 or 360/$35.96 |
| Furosemide 10MG/ML Solution | ROXANE | 60/$16.99 or 180/$32.98 |
| Furosemide 20MG Tablets | SANDOZ | 100/$13.99 or 200/$18.98 |
| Furosemide 40MG Tablets | MYLAN | 100/$13.99 or 200/$19.96 |
| Furosemide 80MG Tablets | MYLAN | 30/$12.99 or 60/$13.98 |
| Lasix 20MG Tablets | AVENTIS | 30/$20.6 or 90/$39.02 |
| Lasix 40MG Tablets | AVENTIS | 30/$23.86 or 90/$46.63 |
| Lasix 80MG Tablets | AVENTIS | 30/$30.37 or 90/$71.58 |
AHFS Drug Information. © Copyright, 1959-2008, Selected Revisions July 2006. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
† Use is not currently included in the labeling approved by the US Food and Drug Administration.
Remember, keep this and all other medicines out of the reach of children,
never share your medicines with others, and use this medication only for the indication prescribed.
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