furosemide : Complexes, Storage & Clinical Research on Healthline.com

Drug	Interaction	Comments
Alcohol	May aggravate orthostatic hypotension
Anticonvulsant agents (e.g., phenytoin sodium, phenobarbital)	Possible reduced diuretic effect
Antidiabetic agents (e.g., insulin, oral agents)	Possible antagonism of hypoglycemic effect as result of hypokalemia	Observe for possible decreased diabetic control; correct potassium deficit and/or adjust dosage of antidiabetic agent
Antihypertensive agents	Additive antihypertensive effect; orthostatic hypotension may occur	Reduce dosage of both drugs Concomitant therapy generally used to therapeutic advantage
Barbiturates	May aggravate orthostatic hypotension
Cardiac glycoside (e.g., digoxin)	Possible electrolyte disturbances (e.g., hypokalemia, hypomagnesemia), increased risk of digitalis toxicity, and/or fatal cardiac arrhythmias	Monitor electrolytes; correct hypokalemia
Chloral hydrate	Possible reaction characterized by diaphoresis, flushes, hypertension, and uneasiness in patients with acute MI and CHF	Consider alternate hypnotic drug (e.g., a benzodiazepine) in patients who require IV furosemide
Diuretics, loop (e.g., bumetanide, ethacrynic acid, torsemide)	Share similar diuretic mechanisms	No therapeutic rationale for concomitant use
Diuretics, potassium- sparing (e.g., amiloride, spironolactone, triamterene)	Possible reduction in potassium loss	May be used to therapeutic advantage
Diuretics, thiazides	Additive diuretic effect	Use reduced dosage of furosemide when added to existing diuretic regimen
Drugs that cause potassium loss (e.g., corticosteroids, corticotropin, amphotericin B)	Additive hypokalemic effects	Monitor electrolytes; correct hypokalemia
Indomethacin	Possible decreased diuretic and natriuretic effect	Monitor closely to determine if desired diuretic and/or hypotensive effect is obtained
Lithium	Reduced renal clearance of lithium and increased risk of lithium toxicity	Avoid concomitant use; if concomitant therapy is necessary, monitor for lithium toxicity
Narcotics	May aggravate orthostatic hypotension
Neuromuscular blocking agents, nondepolarizing (e.g., atracurium besylate, tubocurarine chloride)	Potential for prolonged neuromuscular blockade
Norepinephrine	Decreased arterial responsive to norepinephrine	Norepinephrine may still be used effectively
Ototoxic drugs (e.g., aminoglycoside antibiotics)	Possible additive ototoxic effect, especially in patients with impaired renal function	Avoid concomitant use except in life-threatening situations
Salicylates (e.g., aspirin, NSAIAs)	Possible transient reductions in Cl_cr in patient with chronic renal insufficiency Possible weight gain and increased S_cr, serum potassium concentrations, and BUN (NSAIAs)	Monitor for toxicity
Succinylcholine	May potentiate action of succinylcholine
Sucralfate	Possible reduced natriuretic and antihypertensive effects	Do not administer simultaneously; separate administration by ≥2 hours Observe closely for desired diuretic and/or antihypertensive effect
Uricosuric drugs (probenecid, sulfinpyrazone)	Possible antagonism of uricosuric effects	Monitor serum uric acid concentrations

Furosemide
54 840 20 mg	MYLAN 216 / 40 40 mg	GG 201 40 mg	M2 20 mg
3436 / WATSON 20 mg	MYLAN 232 / 80 80 mg	GG 80 80 mg	54 583 40 mg
WATSON 3437 40 mg	54 533 80 mg	GG 21 20 mg	WATSON 3438 80 mg
WATSON 300 20 mg
Lasix
LASIX (R) 80 / HOECHST 80 mg	LASIX (R) / HOECHST 20 mg	LASIX (R) 40 / HOECHST 40 mg

Drug Notebook

Generic Name: furosemide

Drug Interactions

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